A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol

By Jacqueline L. Blankman, G. Simon, B. Cravatt. Chemistry and Biology, 2007

1,144 citations recorded by the source corpus.

Subfields: Pharmacology, Surgery, Toxicology

View Paper: https://www.semanticscholar.org/paper/dd21a6d589838042e5081c5bc509cdc645698b93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. K. Mackie
2. B. Cravatt
3. Tamás F. Freund
4. Jonathan Z. Long
5. Hui-Chen Lu
6. P. Castillo
7. U. Kumar
8. I. Katona

In Surgery

1. B. Cravatt
2. P. Castillo
3. U. Kumar
4. Tamás F. Freund
5. I. Katona
6. Y. Hashimotodani
7. Shenglong Zou

In Toxicology

1. B. Cravatt
2. Jonathan Z. Long
3. Tamás F. Freund
4. I. Katona

Citations in the corpus

• Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects (2008, background): “Fegley D, et al. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.”
• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system (2010, positive): “1b,c), and confirmed by activity-based protein profiling26,27 that these animals lack detectable MAGL activity without showing alterations in other brain serine hydrolase activities, including FAAH (Fig.”
• Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “How and where does the retrograde 2-AG signal terminate? A recent functional proteomic approach uncovered that 85p of the brain 2-AG content is eliminated by the serine hydrolase MG”
• Endocannabinoid signaling and synaptic function (2012, background): “The fact that most 2-AG is hydrolyzed by MGL (Blankman et al., 2007; Chanda et al., 2010; Nomura et al., 2011) suggests that 2-AG mediates tonic eCBsignaling,which is consistentwith a constitutive release of 2-AG in cultured neurons (Hashimotodani et al.”
• Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “Additionally, a small proportion of 2-AG is also metabolized by the alpha-beta hydrolase (ABHD) class of enzymes, specifically ABHD6 and ABHD12 (Blankman et al, 2007; Marrs et al, 2010; Figure 1).”
• Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “AEA is degraded by fatty acid amide hydrolase (FAAH) into free arachidonic acid and ethanolamine, whereas 2-AG is mostly hydrolyzed by monoacylglycerol lipase (MAGL) into arachidonic acid and glycerol; several other enzymes could be involved as well [9,35,37].”
• An introduction to the endogenous cannabinoid system (2015, background): “It appears to account for the majority of 2-AG hydrolysis in a broad survey of brain 2-AG hydrolytic activity (71).”
• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, methodology): “Since several enzymes have been shown to display MAG hydrolytic activity (Blankman et al., 2007), we confirmed the contribution that MAGL makes to this process in cancer cells using the potent and selective MAGL inhibitor JZL184 (Long et al.”