Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

By Andrei Krivtsov, David Twomey, Zhaohui Feng, Matthew C. Stubbs, Yingzi Wang, Joerg Faber, J. E. Levine, Jing Wang, William C. Hahn, D. Gilliland and 2 more. Nature, 2006

1,590 citations recorded by the source corpus.

Subfields: Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/2f455af422fcc8d51b000a3c169e4c5c71fbbce5

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Citations in the corpus

A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, background): “MLL-associated leukemia models in mice have served as platforms for purifying and examining the gene expression profiles of leukemia stem cells (LSCs, also called leukemia-initiating cells) (Krivtsov et al., 2006).”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Recently, it has been demonstrated that expression of an MLL fusion gene (MLL-AF9) in granulocyte/macrophage progenitors (GMPs) induces a ‘‘HSC stem cell-like’’ signature that includes various HOX genes (Krivtsov et al., 2006).”
The biology of cancer stem cells. (2007, background): “…lacking the ability to selfrenew , more recent evidence suggests that in many cancers the cancer stem cells arise from progenitor cells that have gained the ability to self-renew (Cozzio et al. 2003, Huntly et al. 2004, Krivtsov et al. 2006, Lavau et al. 1997, So et al. 2004, Wagner et al. 2006).”
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “Experimental models suggest that CSCs may originate from normal stem-cells or normal progenitor cells”
Densely interconnected transcriptional circuits control cell states in human hematopoiesis (2011, positive): “However, human leukemias often express more complex combinations of modules that are not observed in normal samples, including HSPC modules, as has been reported in murine models of leukemia (Krivtsov et al., 2006).”
Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. (2008, background): “As an independent predictive factor of resistance, we have identified a HOX-dominated gene cluster, evocative of a self-renewal signature recently described for leukemia.(9) Strong HOXA10 expression of glioblastoma-derived neurospheres is in line with a role of HOX genes in the glioma stem-like cell”
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007, background): “The critical requirement of appropriate control of such factors in oligopotent—but normally not self-renewing—progenitors has been highlighted by the development of leukemias arising as a consequence of the misappropriate expression of such transcriptional regulators (Cozzio et al., 2003; Krivtsov e”
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. (2007, methodology): “We then analyzed the gene expression data using gene set enrichment analysis (GSEA; Krivtsov et al., 2006; Subramanian et al., 2005), a computational method that determines if a defined gene set shows differential expression between two biological states (http://www.broad.mit. edu/gsea/).”