Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

By Yimin Fang, M. Vilella-Bach, Rebecca A. Bachmann, Asa Flanigan, Jie Chen. Science, 2001

1,072 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2f1bdce0bca9ff5556e0c237c232b92fc64fe1e5

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In Molecular Biology

Citations in the corpus

Upstream and downstream of mTOR. (2004, background): “PA was shown to bind the mTOR FRB domain and activates mTOR (Fang et al. 2001).”
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “For instance, the activation of CaMKII leads to phosphorylation and nuclear exclusion of HDAC4, which relieves repression of MEF2 (Liu et al., 2005).”
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. (2007, background): “(34) have reported that p53 activates autophagy in response to etoposide treatment through inhibition of mammalian Figure 5.”
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004, background): “In addition, a rapamycin-resistant mutant of S6K1 (DNT/CT) was insensitive to 1- and 2-butanol-induced inactivation (1- and 2-butanol block PA production by PLD), indicating that PA signals to S6K1 via mTOR (Fang et al., 2001).”
mTOR signaling in growth control and disease (2012, background): “Finally, phosphatidic acid (PA) has also been identified as an activator of mTORC1 (Fang et al., 2001).”
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. (2002, background): “mTOR may also respond to mitogenic signals (Scott et al. 1998; Sekulic et al. 2000; Fang et al. 2001).”
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. (2003, positive): “Genetic data from Drosophila show that TSC1 and TSC2 negatively regulate cell growth and cell size (Gao and Pan 2001; Potter et al. 2001; Tapon et al. 2001).”
Rapamycin passes the torch: a new generation of mTOR inhibitors (2011, background): “Phosphatidic acid has been proposed as an activator of both mTORC1 and mTORC2 (REF”
Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway (2005, background): “Another activator of mTOR is phosphatidic acid (Fang et al., 2001), which is generated by phospholipase D.”
TOR signalling in bugs, brain and brawn (2003, background): “Furthermore, mTOR seems to respond positively to phosphatidic acid and ATP, both of which are produced in response to growth factor”