A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

By D. Presky, H. Yang, L. Minetti, A. O. Chua, N. Nabavi, Chang‐you Wu, M. Gately, U. Gubler. 1996

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Citations in the corpus

The composition and signaling of the IL-35 receptor are unconventional (2012, result): “In both Rag1 −/− mice and tumor models, T cells lacking just one of the IL-35R chains (IL-12Rβ2 or gp130) were still suppressed by IL-35 in a manner indistinguishable from that of wild-type cells, which further suggested that IL-35 can mediate signaling via a single receptor chain in vivo , in c”
The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression1 (2000, background): “In addition, 10mM SB203580 did not affect IL-12-induced tyrosine phosphorylation of Jak2 (data not shown), consistent with the above result.”
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis (2006, background): “The heterodimeric receptors for IL-23 and IL-12 consist of IL-23R paired with IL-12Rβ1 and IL-12Rβ2 paired with IL-12Rβ1, respectively (11, 12).”
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells (2002, background): “Naive CD4 + T cells express functional IFN-γ receptors, but induce and maintain expression of the IL-12 receptor (IL-12R) signaling subunit IL-12Rβ2 only after activation in appropriate cytokine condition”
The biology of IL-12: coordinating innate and adaptive immune responses. (2003, background): “[55] Presky DH, et al.”
Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab (2011, background): “A heterodimer comprising covalently linked p40 and p35 protein subunits, IL-12 binds to a heterodimeric receptor complex consisting of IL-12 receptor (IL-12R)β1 and IL-12Rβ2 chains expressed on the surface of T cells or natural killer cell”
Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells (1997, background): “Expression of the IL-12R b2 subunit is required for recruitment and activation of the STAT proteins involved in IL-12 signaling (37).”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “IL-12 is a combination of the p40 and p35 alpha and beta subunits, respectively, and binds the IL-12 receptor (IL-12R) complex, IL-12Rβ1/IL-12Rβ2 (179).”
IL‐12 and IL‐23: master regulators of innate and adaptive immunity (2004, background): “The high-affinity IL-12 receptor complex is comprised of an IL-12Rb1 and IL-12Rb2 subunit (10, 11).”