The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression1

By Shangming Zhang, M. Kaplan. Journal of Immunology, 2000

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Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “The p38-MAPK pathway is critical for the production of inflammatory cytokines, positively regulating the production of IFN-γ in CD4 and CD8 cells (187, 188).”
Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL‐12 responses (2003, background): “IL-12 has also been reported to activate p38 MAPK (Visconti et al., 2000; Zhang and Kaplan, 2000), which is involved in the phosphorylation of Stat4 Ser721, contained in the transactivation domain, to increase Stat4-dependent transactivation.”
GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4‐independent IFNγ production in T cells (2004, background): “These results suggest that TCR signaling appears to be largely intact in MEKK4 / primary T cells. p38 MAPK is known to have an important role in mediating IL12-driven IFNg production in developing CD4 T cells (Rincon et al, 1998; Lu et al, 1999; Zhang and Kaplan, 2000).”