Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories

By S. Heldt, L. Stanek, J. Chhatwal, K. Ressler. Molecular Psychiatry, 2007

703 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/2f0c06fc6f942e4bd9f9cdaa1cc4270e2daf59ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “However, BDNF, which is known to be important for various aspects of hippocampal plasticity including neurogenesis and spatial memory (90, 116, 202), is not the only mediator of the effects of T cells on the hippocampus.”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “…its multiple developmental roles, complicating analysis of its role in learning and memory; but recent studies that have disrupted BDNF only in the adult animal indicate a critical role in information processing and storage (Monteggia et al, 2004; Heldt et al, 2007; reviewed in Pang and Lu, 2004).”
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease (2009, background): “Within the adult hippocampus, BDNF in particular, plays a central role in the synaptic remodeling associated with memory (22).”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “For example, BDNF could be a mediator of the plastic changes underlying both spatial and recognition memory processes (Kesslak et al., 1998; Mizuno et al., 2000; Cirulli et al., 2004; Bekinschtein et al., 2007; Heldt et al., 2007).”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “As described above (Section 1.4.3.3), BDNF has been implicated in hippocampal-dependent memory (Barnes and Thomas, 2008; Heldt et al., 2007), LTP (Lu et al., 2008) and neurogenesis (Li et al., 2008).”
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress (2012, background): “Failure to recall extinction in rats is correlated with decreased excitability in IL neurons (Burgos-Robles et al 2007, Santini et al 2008), and decreased BDNF in the hippocampus (Heldt et al 2007, Peters et al 2010).”
Neural Mechanisms of Extinction Learning and Retrieval (2008, result): “Consistent with findings in the amygdala (Chhatwal et al, 2006), lentiviral inactivation of BDNF in the hippocampus impairs consolidation of fear extinction in a cued fear conditioning paradigm (Heldt et al, 2007).”
Bacterial infection causes stress-induced memory dysfunction in mice (2010, background): “Hippocampus-specific deletion of BDNF causes impaired spatial and object recognition.(61) Additionally, NMDA receptors in the CA1 region of the hippocampus participate in non-spatial memory formation.”
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “Hippocampal deletion of BDNF leads to disrupted extinction of fear memory (Heldt et al., 2007).”