Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

By M. Brengues, Daniela Teixeira, R. Parker. Science, 2005

829 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2eb6c26677a6d78845c6e1022144a3b2f8cc2421

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Citations in the corpus

P bodies: at the crossroads of post-transcriptional pathways (2007, background): “cerevisiae , the visualization of P bodies is often enhanced by overexpressing or depleting some of the P-body components or by exposing yeast cells to stresses such as glucose deprivation or hypotonic shoc”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “In contrast, translation inhibition is reversible because stable mRNA can be translated following elimination of translation repression [165, 174-177].”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “It should be noted that because P-bodies are dynamic structures and, at least in yeast, mRNAs can cycle in and out of P-bodies (Brengues et al. 2005), the translation repression by RISC could be a kinetic effect on either increasing the rate of entry into P-bodies or decreasing the exit rate of mRNA”
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. (2007, background): “These bodies have been implicated in RNAi- and miRNA-mediated silencing but have also been shown to be able to release mRNAs into the actively translating pool of mRNAs (Brengues et al., 2005), suggesting that they may act as mRNA-storage particles.”
How do microRNAs regulate gene expression? (2008, background): “Entry of an mRNA into Dcp1/Dcp2 foci does not inevitably lead to its degradation, as shown by the fact that glucose starvation of yeast, which results in a global inhibition of initiation, drives mRNAs into P-bodies, but on refeeding they exit the foci and become (re)assimilated into active polysome”
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. (2017, background): “Yet other studies suggest that repressed mRNAs may Molecular Cell 68, 1–14, October 5, 2017 ª 2017 Elsevier Inc. 1 return from P-bodies to the cytosol to reenter translation (Bhattacharyya et al., 2006; Brengues et al., 2005).”
Mechanisms of microRNA‐mediated gene regulation (2007, background): “The latter outcome (stasis) is suggested by experiments in budding yeast showing that P bodies can be a repository for untranslated mRNAs [ 40 ] and is supported by an example from mammalian cells in which a specific mRNA seems to be sequestered from ribosomes in an miRNA-dependent manner [29].”
RNA granules: post-transcriptional and epigenetic modulators of gene expression (2009, background): “Because mRNPs can leave the PB to resume translatio”
mRNA capping: biological functions and applications (2016, positive): “Uncapped mRNA in P-bodies can re-enter polysome and be translated (21).”
Eukaryotic stress granules: the ins and outs of translation. (2009, background): “Because mRNAs within P-bodies can return to translation (Brengues et al., 2005; Bhattacharyya et al., 2006), one would expect a priori that mRNPs within P-bodies can exchange proteins to form mRNPs competent for translation initiation.”