Antibiotic growth promoters in agriculture: history and mode of action.

By J. Dibner, J. D. Richards, J. Dibner. Poultry Science, 2005

1,446 citations recorded by the source corpus.

This report will review the history of antibiotic growth promoter (AGP) use in the animal industry, concerns about development of antimicrobial resistance, and response in the European Union and United States to these concerns. A brief description of the history of legislation regarding feed use of antimicrobials in Denmark and the experience of animal producers following the 1998 ban will serve to illustrate the consequences on animal performance and health of withdrawing the approval for this use. The biological basis for antibiotic effects on animal growth efficiency will consider effects on intestinal microbiota and effects on the host animal and will use the germ-free animal to illustrate effects of the conventional microflora. The probability that no single compound will replace all of the functions of antimicrobial growth promoters will be considered, and methods to consolidate and analyze the enlarging database will be discussed.

Subfields: Agronomy and Crop Science, Animal Science and Zoology, Pollution

View Paper: https://www.semanticscholar.org/paper/2e97b73de03b163bd4a57acf9fb30bf0ad57edcf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Agronomy and Crop Science

1. Y. Yang
2. P. Iji
3. M. Choct

In Animal Science and Zoology

1. Y. Yang
2. P. Iji
3. M. Choct
4. H. Lillehoj
5. F. Gaggía
6. G. Schatzmayr
7. B. Biavati
8. C. Nyachoti

In Pollution

1. James M. Tiedje
2. Yong-guan Zhu
3. S. Khan
4. Javid Iqbal

Citations in the corpus

• Antibiotic-Producing Bacteria as a Possible Defence of Birds against Pathogenic Microorganisms (2010, background): “In accordance with a positive effect of antibiotic substances in the gastrointestinal tract, it has experimentally been shown that feeding with antibiotics enhances growth of wild [23] and domestic birds [24].”
• Intestinal microbiome of poultry and its interaction with host and diet (2014, background): “Although the precise mode of action of AGPs still remains to be elucidated, it is widely accepted that the growth-promoting effect of AGPs is primarily brought about through modulation of intestinal microbiome.(88) Adverse and pathogenic bacteria in the GI tract of chicken, such as E.”
• Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity (2016, background): “…Poultry Science Journal, Vol. 72, June 2016 Received for publication September 29, 2015 Accepted for publication March 1, 2016 265 until questioned due to increasing frequency of resistance to antibiotics in chicken (Kabir, 2009) along with dwindling efficacy in humans (Dibner and Richards, 2005).”
• An update on alternatives to antimicrobial growth promoters for broilers. (2011, background): “In other countries, such as the USA, consumer pressure is pushing the poultry industry to rear animals without AGPs (Dibner and Richards, 2005; Castanon, 2007).”
• Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review (2017, background): “Despite these debates on the role of IFA use in conferring antimicrobial resistance to human pathogens, the European Union issued a ban on the approval for antibiotics as growth promoters since 1 January 2006 on precautionary grounds (Dibner and Richards, 2005; Castanon, 2007).”
• Evaluation of Multi-microbial Probiotics Produced by Submerged Liquid and Solid Substrate Fermentation Methods in Broilers (2010, background): “The benefits of feeding antibiotic growth promoters have been reviewed previously (Ferket, 2004; Dibner and Richards, 2005; Denev, 2006).”
• Dietary modulation of gut microflora in broiler chickens: a review of the role of six kinds of alternatives to in-feed antibiotics (2009, background): “However, because of the development of resistance by pathogenic bacteria, which can impact on public health, antibiotics are being taken out of poultry and pig diets around the world, beginning in Sweden in the year 1986 (Dibner and Richards, 2005).”
• The Economic Costs of Withdrawing Antimicrobial Growth Promoters from the Livestock Sector (2015, background): “OECD FOOD, AGRICULTURE AND FISHERIES PAPER N°78 © OECD 2015 reducing growth-depressing microbial metabolites in animals (Dibner and Richards, 2005; Gaskins et al., 2002).”
• Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. (2013, background): “Indeed, improved performance could be due to a combination of reduced total intestinal biota biomass and elimination of the harmful bacteria (Dibner and Richards, 2005).”
• Review of antibiotic resistance in China and its environment. (2018, neutral): “Its use as a growth promoter increased year on year, despite the recognition that such a practice selected for resistance in the animals, farmers and veterinarians (Dibner and Richards, 2005; Marshall and Levy, 2011).”
• History of the use of antibiotic as growth promoters in European poultry feeds. (2007, background): “The mechanism of action of antibiotics as growth promoters is related to interactions with intestinal microbial population (Dibner and Richards, 2005; Niewold, 2007).”
• Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential (2010, background): “2002) has led to the ban on the use of conventional antibiotics in 16 livestock foodstuffs in the European Union (European Union, 2005) and similar bans 17 are being considered elsewhere (Dibner and Richards 2005).”
• Effect of Dietary Garlic (Allium sativum) Supplementation as Feed Additive on Broiler Performance and Blood Profile (2013, background): “Garlic has been used for about 50 years as antibiotic growth promoters and to enhance growth performance in poultry and swine Dibner and Richards (2005) and Demir et al. (2008).”
• Effect of Formic Acid and Plant Extracts on Growth, Nutrient Digestibility, Intestine Mucosa Morphology, and Meat Yield of Broilers (2007, background): “On the other hand, additional effects of AGP on parameters other than performance that also occur in germ-free animals include a reduction in gut size, including thinner intestinal villi and total gut wall, which result in a sparing use of the nutrients and an improvement in performance [32].”
• Probiotics and phytogenics for poultry: myth or reality? (2010, background): “Regardless of the fact that the exact mechanisms of antibiotic-mediated growth promotion are currently incompletely understood, most researchers support the theory that antibiotics reduce the overall numbers of gut bacteria, which may promote growth [5].”
• Effect of Using Organic Acids to Substitute Antibiotic Growth Promoters on Performance and Intestinal Microflora of Broilers (2010, background): “Antibiotics have been given at sub therapeutic dosage (as feed additive) to stabilize the intestinal microflora and improve the general performances and prevent some specific intestinal pathology promote growth for about 50 years (Dibner and Richards, 2005).”