AP-1 in cell proliferation and survival

By E. Shaulian, M. Karin. Oncogene, 2001

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Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases (2011, background): “AP-1 activity is required for expression of cyclin D1 (327), a protein that interacts with cyclin-dependent kinases (CDKs) and permits G1/S transition and cell cycle progression.”
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “c-Jun is also a negative regulator of p53 expression and fibroblast cells expressing constitutive levels of c-Jun express lower levels of both p53 and the p53-regulated cyclin-dependant kinase inhibitor p21 and fail to undergo growth arrest following UV exposure [106].”
Role of ζPKC in B‐cell signaling and function (2002, background): “This is particularly relevant in the light of the role that c-Fos plays in cell survival and growth (Shaulian and Karin, 2001).”
Oxidative Stress in Cancer (2020, background): “AP-1 members include oncogenes that can transform cells and are involved in cell proliferation, while others inhibit tumorigenesis, suggesting that their effects are context dependent (Eferl and Wagner, 2003; Shaulian and Karin, 2001).”
Inflammation: gearing the journey to cancer. (2008, neutral): “, p53, Bax, and Bad) [35,199,200].”