Role of ζPKC in B‐cell signaling and function

By Pilar Martín, A. Duran, S. Minguet, M. Gaspar, M. Diaz-Meco, P. Rennert, M. Leitges, J. Moscat. 2002

136 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/958f21a918955bea17e07202112645ff071344b6

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In Cancer Research

1. J. Moscat
2. M. Diaz-Meco
3. A. Duran
4. P. Rennert

In Molecular Biology

1. M. Diaz-Meco
2. J. Moscat
3. A. Duran

In Oncology

1. J. Moscat
2. P. Rennert

Citations in the corpus

• NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, background): “Interestingly, after challenge with IgM, PKC-ζ, but not the other atypical PKC-λ/ι, is phosphorylated in its T-loop, which is required for PKC-ζ activity (Martin et al., 2002).”
• Essential role of RelA Ser311 phosphorylation by ζPKC in NF‐κB transcriptional activation (2003, methodology): “In B cells, it is clear that the loss of zPKC inhibits the synthesis of a number of kB-dependent genes with no effects on NF-kB nuclear translocation, as determined by electrophoretic mobility shift assays (EMSAs) (Martin et al., 2002).”