TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

By K. Du, S. Herzig, R. Kulkarni, M. Montminy. Science, 2003

895 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/2df5eb97d07737225ab340f81e97707c14f5ca5d

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In Cell Biology

1. Afshin Samali
2. A. Gorman
3. Jonathan H. Lin
4. P. Boya
5. Peter Walter
6. T. Yen
7. E. Szegezdi
8. S. Logue

In Molecular Biology

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In Surgery

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4. Jonathan H. Lin

Citations in the corpus

• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. (2009, background): “TRB3 has been previously shown to inhibit Akt (21, 22), although the precise contribution of this pseudo-kinase to the regulation of Akt activity in different cellular contexts is unclear (32).”
• Endoplasmic reticulum stress in disease pathogenesis. (2008, background): “CHOP can cause cell death by increasing the amount of GADD34, which restores translation, and by increasing oxidative stress (24, 25), but there may be other mechanisms by which CHOP's transcriptional output promotes cell death, such as by increasing the expression of TRB3 (26).”
• PI3K/Akt and apoptosis: size matters (2003, methodology): “In mammals, three closely related isoforms of Akt are encoded by distinct genetic loci: Akt (that in fact is Akt1), Akt2 and Akt3.”
• TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death (2005, methodology): “In addition, the deletion of carboxylterminal region or Akt-binding site (239–265) (Du et al, 2003) on TRB3 did not affect the binding with CHOP; however, these mutants lost CHOP repression ability like TRB3 DN”
• The role of FoxO in the regulation of metabolism (2008, background): “Trb3 is a scaffolding protein that binds Akt and prevents insulininduced Akt phosphorylation (Du et al., 2003).”
• The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “On the other hand, a pseudokinase, namely Tribbles homolog 3, binds to and inhibits AKT, which leads to insulin resistance (Du et al., 2003).”
• Regulation of energy metabolism by long-chain fatty acids. (2014, background): “Because TRB3 acts as an inhibitor of Akt signaling [115], insulin signaling may be attenuated in liver of PPARa KO mice (Fig.”
• Mediators of endoplasmic reticulum stress‐induced apoptosis (2006, background): “…not in ER stress, have indicated that it might promote apoptosis by binding to the pro-survival serine/ threonine kinase Akt, thereby preventing its phosphorylation and ©2006 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION EMBO reports VOL 7 | NO 9 | 2006 883 reducing its kinase activity (Du et al, 2003).”