PI3K/Akt and apoptosis: size matters

By T. Franke, C. Hornik, Lisa Segev, Grigoriy A Shostak, C. Sugimoto. Oncogene, 2003

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PI3K/Akt: getting it right matters (2008, background): “…cell size matters Although Akt promotes cell proliferation by regulating specific targets related to the cell cycle machinery and to DNA damage-dependent cell responses, a conserved function of PI3K/Akt signal transduction is found in regulating cell volume (for review, see Franke et al., 2003).”
Mitochondrial membrane permeabilization in cell death. (2007, background): “tion, carcinogenesis, and as recently discovered, apoptosis (84, 224).”
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. (2016, background): “Inhibition of GSK3 by PI3 K/AKT activation destroys GSK3-mediated p21 phosphorylation at Thr-57 and increases p21 half-life (Fig.”
A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007, background): “…possibility is that posttranslational regulation of anti-apoptotic or proapoptotic proteins through Akt/PKB-mediated phosphorylation results in their activation or inactivation, respectively, and thus exerts an antagonistic effect on PKR-mediated apoptosis (Franke et al., 2003; Downward, 2004).”
Autophagy: dual roles in life and death? (2005, background): “Several studies have shown that PI3K and Akt signalling enables cell survival (reviewed in Ref”