Computational approaches to cellular rhythms

By Albert Goldbeter. Nature, 2002

596 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Modeling the cell cycle: why do certain circuits oscillate? (2011, unknown): “Indeed, some of the earliest models of the cell cycle were simple three-ODE negative feedback loops (Goldbeter, 1991).”
Automated refinement and inference of analytical models for metabolic networks (2011, background): “Models of such systems can aid in recreating phenomena such as glycolytic oscillations [55] with the help of tools that are also used in many other disciplines [56] to study behavior such as bifurcations and limit cycles.”
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2 (2003, background): “, and oscillators with bistable triggers may be particularly relevant to biological applications such as cell cycle regulatio”
Cell-signalling dynamics in time and space (2006, background): “Positive feedback greatly increases the sensitivity of the target to the signal and might also lead to bistability and relaxation oscillations 12,18,46,72”