Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

By S. Maeda, L. Hsu, Hongjun Liu, L. Bankston, M. Iimura, M. Kagnoff, L. Eckmann, M. Karin. Science, 2005

735 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/2cffcaf802f356dbe005340dfd1db82f2e6c73a0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Annick Mayor
2. J. Tschopp
3. Fabio Martinon
4. G. Núñez
5. M. Karin
6. T. Lawrence

In Genetics

1. J. Tschopp
2. G. Núñez
3. M. Karin
4. C. Harris
5. Fabio Martinon
6. M. Abreu
7. V. Nizet
8. Steven W. Gangestad

In Immunology

1. J. Tschopp
2. M. Karin
3. G. Núñez
4. Fabio Martinon
5. Annick Mayor
6. T. Lawrence
7. N. Warner
8. V. Nizet

Citations in the corpus

• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Inhibition of IL-1b signaling by injection of IL-1 receptor antagonist (IL-1Ra) inhibited DSS-induced colonic inflammation and abolished the phenotypic differences between the Nod2 knockin mice and wild-type counterparts (Maeda et al., 2005a).”
• Inflammation and cancer: An ancient link with novel potentials (2007, background): “These mutations enhance NF-jB activity and increased the production of IL-1b.(79) Although the majority of evidence supports a role of NF-jB in tumor progression, its antitumorigenic function has also been reported in certain cell types (reviewed in Ref.”
• TLR Signaling in the Gut in Health and Disease1 (2005, background): “E-mail address: Maria.Abreu@mssm.edu 3 Abbreviations used in this paper: NOD, nucleotide oligomerization domain; PAMP, pathogen-associated molecular pattern; IEC, intestinal epithelial cell; LTA, lipotechoic acid; IRAK, IL-1 receptor-associated kinase; IBD, inflammatory bowel disease; DSS, dextran s”
• The inflammasomes: guardians of the body. (2009, background): “NOD2 has also been suggested to play a role, together with NALP1, in MDP-induced caspase-1 activation, further suggesting that multiple NLRs may cooperate and synergize to mount host defenses (68, 165).”
• The gut flora as a forgotten organ (2006, background): “For example, TLR2 is activated by peptidoglycan and lipotechoic acids, TLR4 by lipopolysaccharide, TLR5 by flagellin, and NOD1/ CARD4 and NOD2/CARD15 function as intracellular receptors of peptidoglycan subunits.”