Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

By H. Parri, Timothy M. Gould, V. Crunelli. Nature Neuroscience, 2001

615 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/2cb61312b7e0f0983c5b59e34f7d6318b8fdf556

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Citations in the corpus

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo (2006, background): “In contrast, a large body of evidence has documented that astrocytes can trigger increases in neuronal Ca 2+ in groups of neuron”
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation (2003, background): “Astrocytes can sense neuronal activity and provide a feedback mechanism that, through the release of glutamate, profoundly affects the communication between neuron”
Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats (2003, background): “Excitation of glia at one site can activate distant glia, causing them to release pain-enhancing substances as well (Hassinger et al., 1995; Innocenti et al., 2000; Parri et al., 2001).”
Glutamate exocytosis from astrocytes controls synaptic strength (2007, background): “It should be noted that activation of NMDARs by NMDA in Mg 2+ -containing medium has already been reporte”
Heterogeneity of Astrocytic Form and Function (2012, neutral): “Astrocytes in the cortex and hippocampus have been shown to release ATP and glutamate leading both to excitation and inhibition of neuronal activity (69, 79).”
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate (2004, background): “This event may depend on either an intrinsic oscillatory activit”
Glial regulation of the cerebral microvasculature (2007, background): “Furthermore, astrocytes ex vivo have been shown to have intrinsic excitability or spontaneous increases in cytosolic Ca 2+ that are not inhibited by known receptor antagonist”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “Glia communicate with each other and with neurons by propagating their signals as Ca(2) waves (469).”
Astrocyte-mediated control of cerebral blood flow (2006, background): “Therefore neuron to astrocyte signaling is, at least in part, mediated by the synaptic release of glutamate, which triggers increase in astrocytic Ca 2+ by an mGluR5 receptor–dependent pathwa”
Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. (2004, neutral): “…at a physiological concentration of Mg2 was similarly raise the possibility that astrocytes contribute to the observed in the ventrobasal thalamus (Parri et al., 2001). formation of the basal functional module in brain inforWhile the mechanism leading to the removal of the Mg2 mation processing.…”