Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors.

By Tommaso Fellin, O. Pascual, S. Gobbo, T. Pozzan, Philip Haydon, Giorgio Carmignoto. Neuron, 2004

999 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/5ca7cd1b5eab8fd41317056c1fe6dad7eda58d3d

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Glutamate exocytosis from astrocytes controls synaptic strength (2007, background): “We further considered the possible involvement of extrasynaptic NR2B-containing receptors, as in CA1 pyramidal neurons these receptors are activated by glutamate released from astrocytes and mediate characteristic ifenprodil-sensitive slow inward currents (SICs”
Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “Measurement of the kinetics of SICs in brain slice studies showed that they are very slow compared with synaptic NMDA currents (8, 54).”
Synaptic Islands Defined by the Territory of a Single Astrocyte (2007, background): “Confocal imaging of Ca 2 indicators reveals that an average of two to three, but up to 12, hippocampal pyramidal neurons per optical section are synchronously activated by glutamate released from astrocytes (Fellin et al., 2004).”
Glia-derived D-serine controls NMDA receptor activity and synaptic memory. (2006, neutral): “Although the transmitters mediating such glia-toneuron signaling are generally considered to be glutamate (Angulo et al., 2004; Fellin et al., 2004 ) or ATP (Gordon et al., 2005; Newman, 2003; Zhang et al., 2003), it is now obvious that another important gliotransmitter is the amino acid D-serine (”
Gliotransmitters Travel in Time and Space (2014, positive): “, 2004) and to favor neuronal synchrony by acting on postsynaptic NMDARs (Fellin et al., 2004).”
Amyloid-β Induced Neuronal Dysfunction in Alzheimer’s Disease: From Synapses toward Neural Networks (2010, background): “Spontaneous or neuron-induced rises in astroglial [Ca 2+ ] i can release glutamate and activate extrasynaptic NR2B subunit–containing NMDARs on neurons, promoting neuronal excitability and synchronized firing in hippocampal pyramidal neuron”
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo (2006, background): “In vitro studies indicate that group I mGluR, particularly mGluR 1 and mGluR 5, have a key role in synapse-induced astrocytic Ca 2+ signalin”