Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

By U. Hink, Huige Li, H. Mollnau, M. Oelze, Edi Matheis, Mark Hartmann, M. Skatchkov, F. Thaiss, Rolf A. K. Stahl, A. Warnholtz and 5 more. Circulation Research, 2001

1,220 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/2cad1ce07ee5797a9f600e52d6c9cf61980be6d9

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In Biochemistry

1. A. Shah
2. M. Valko
3. Jian-Mei Li
4. U. Förstermann
5. R. Clempus
6. B. Lassègue

In Immunology

1. R. Clempus
2. B. Lassègue
3. A. Shah
4. Jian-Mei Li
5. U. Förstermann
6. Rhian M. Touyz
7. E. Schiffrin
8. S. Dikalov

In Physiology

1. R. Clempus
2. A. Shah
3. B. Lassègue
4. Antonio Ceriello
5. F. Cosentino
6. Joshua A. Beckman
7. G. King
8. M. Valko

Citations in the corpus

• New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. (2003, background): “The activation of protein kinase C, due to superoxide overproduction, induces a de novo synthesis of the enzyme NAD(P)H oxidase, which significantly contributes to produce more superoxide anions (32).”
• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “Endothelial NADPH oxidase activity is increased by 1) mechanical forces such as oscillatory shear stress (67); 2) hypoxia-reoxygenation (77, 136, 141), flow cessation (111), membrane depolarization (4, 140), nutrient deprivation (106), or ischemia (4, 111); 3) G protein-coupled receptor agonists suc”
• Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. (2005, neutral): “…syndromes (20–22), but the literature lacks data on EPC variations in the presence of PVD. Diabetes mellitus is characterized by endothelial dysfunction (23–25) and a three-to four-fold increase in cardio-vascular risk, and diabetic vasculopathy is an important source of morbidity and mortality.”
• Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. (2004, neutral): “in vitro chemical assays, coelenterazine-dependent chemiluminescence has been used in cultured cells (25), neutrophils (77), vascular tissues (51, 121, 131), and isolated mitochondria (104).”
• Vascular complications of diabetes: mechanisms of injury and protective factors (2013, background): “Expression and activity of vascular NADH oxidase are increased in rat models of type 1 (Hink et al., 2001) and type 2 (Kim et al., 2002) diabetes.”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, background): “Finally, the mRNAs of the major phagocytic NAD(P)H oxidase subunits p22phox and gp91phox were upregulated in vessels from diabetic animals (80, 91, 94), as well as p22phox, p47phox, and p67phox proteins in vessels from diabetic patients (68).”
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “The superoxide generated by eNOS uncoupling has been implicated in a variety of inflammatory conditions, including acute lung injury (385), diabetes mellitus (178), and Ang II-induced hypertension (298).”