Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

By Luis Ulloa, M. Ochani, Huan Yang, Mahira Tanović, D. Halperin, Runkuan Yang, C. Czura, M. Fink, Kevin J. Tracey. Proceedings of the National Academy of Sciences of the United States of America, 2002

612 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Immunology

View Paper: https://www.semanticscholar.org/paper/2c93b84eddb796d4354c646ff0c88de1dafa82b8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. D. Tang
2. R. Kang
3. Michael Lotze
4. H. J. Zeh
5. Kevin J. Tracey
6. U. Andersson
7. M. Bianchi
8. C. Deutschman

In Immunology

1. Michael Lotze
2. D. Tang
3. R. Kang
4. Kevin J. Tracey
5. H. J. Zeh
6. U. Andersson
7. M. Bianchi
8. C. Deutschman

Citations in the corpus

• Sepsis: current dogma and new perspectives. (2014, background): “Inhibition of HMGB1 by administration of specific, neutralizing monoclonal antibodies or by pharmacological agents that suppress serum HMGB1 concentrations confers survival advantages to animals with severe sepsis and protects against impaired organ function and homeostasis (Qin et al., 2006; Ulloa ”
• Novel strategies for the treatment of sepsis (2003, background): “Ethyl pyruvate, which inhibits HMGB1 production in vivo , improves survival in a sepsis model in mice when administered 24 h after onset of sepsi”
• Endogenous HMGB1 regulates autophagy (2010, background): “Thus, we determined the effect of HMGB1 on the interaction between 887HMGB1 regulates autophagy • Tang et al. cytoplasmic translocation by ethyl pyruvate (Ulloa et al., 2002) blocked starvationinduced aggregation of LC3 punctae (Fig.”
• The inflammatory reflex (2002, background): “Reducing serum concentrations of HMGB1 by administering ethyl pyruvate as late as 24 h after the onset of sepsis rescues animals from lethality, indicating that it may now be possible to develop therapies for sepsis that cover a significantly wider, clinically relevant treatment windo”
• HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection (2011, background): “Ethyl pyruvate, an aliphatic ester derived from pyruvic acid, decreases the nuclear translocation of NF-κB, significantly inhibits HMGB1 release, ameliorates organ dysfunction, and improves survival in CLP, even when therapy is delayed for 24 h after the onset of infection (45).”