Novel strategies for the treatment of sepsis

By N. Riedemann, R. Guo, P. Ward. Nature Medicine, 2003

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Acute Chorioamnionitis and Funisitis: Definition, Pathologic Features, and Clinical Significance (2015, background): “SIRS can occur in cases of sterile inflammation (eg, pancreatitis or burns).(346,352) Since the original report”
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005, methodology): “ROS are an important target for treatment of sepsis, and various antioxidants have been used in clinical sepsis trial”
The enigma of sepsis. (2003, neutral): “Experimental data support the theory that an early intense proinflammatory response of the immune system after infection or trauma can cause harm or set the stage for subsequent organ damage, but it is also well documented that, during sepsis, the innate immune system frequently loses the ability to”
The fetal inflammatory response syndrome. (2007, background): “SIRS and sepsis are the main causes of death of patients admitted to intensive care units, with mortality rates ranging from 30% to 70% despite more than 20 years of intensive basic and clinical research.(3,4) The original definition of SIRS in adults was proposed in 1992 by the American College of ”