Mitochondrial free radical generation, oxidative stress, and aging.

By E. Cadenas, K. Davies. Free Radical Biology & Medicine, 2000

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How researchers see this paper

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Mitochondrial formation of reactive oxygen species (2003, background): “As a result, the steady state concentrations of O2 _• and H2O2 have been estimated to be around 10_10 M and 5 w 10_9 M, respectively (Cadenas & Davies, 2000).”
Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “Furthermore, dysregulation, and specifically upregulation, of metabolism-derived H2O2 may play an important role in certain disorders such as aging (38, 175).”
Studies on free radicals, antioxidants, and co-factors (2007, background): “The number of people aged 65 and over is predicted to increase by approximately 53% in the United Kingdom by the year 2031 and similar changes are likely to be seen in other developed countries due to low birth rates and increasing life expectancy, which will lead to an increasingly elderly…”
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, positive): “Moreover, due to the significant roles of mitochondrial impairments in the aging processes (47, 265), it is conceivable that NAD may further influence aging by its profound effects on mitochondrial activities.”
The sites and topology of mitochondrial superoxide production (2010, background): “In ageing, there is good evidence for the importance of mitochondrial ROS generation (Cadenas and Davies, 2000).”