The key to development: interpreting the histone code?

By R. Margueron, P. Trojer, D. Reinberg. Current Opinion in Genetics and Development, 2005

808 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2b999582ffe0c377ef9d3f3aef6fca24dc4bc825

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Citations in the corpus

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. (2007, background): “…modifications of core histones, such as methylation and acetylation, are correlated with the conformational state of chromatin and the transcriptional status of genes (Cosgrove and Wolberger, 2005; Fischle et al., 2003; Jenuwein and Allis, 2001; Margueron et al., 2005; Turner, 2000).”
Ensembl regulation resources (2016, background): “Complex interactions with polymerases, transcription factors (TF) and enzymes that modify histones and DNA (1–3) as well as its spatial structure (4, 5) largely determine the functional activity of the cell’s chromatin, in particular the controlled transcription of genes (6), which in turn controls ”
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification (2011, neutral): “PTM-inducedchanges inprotein interactions between chromatin and its binding partners are in turn translated into biological outcomes (Margueron et al., 2005).”
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome (2007, background): “of ever-increasing complexity with profound implications for chromatin as both a receptive substrate and a predictive signal in a variety of biological processe”
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, neutral): “Perhaps this is why histone methyl ‘‘writers’’ and ‘‘readers’’ are so instrumental during mammalian development (Margueron et al., 2005).”
The histone methyltransferase Wolf–Hirschhorn syndrome candidate 1‐like 1 (WHSC1L1) is involved in human carcinogenesis (2013, background): “…of the amino termini of histones H3 and H4 and the amino and carboxyl termini of histones H2A, H2B, and H1, are susceptible to a variety of post-translational modifications such as phosphorylation, acetylation, methylation, ubiquitination, sumoylation, and glycosylation (Margueron et al., 2005).”
Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Different PTMs form a complex regulatory program with characteristics of a sophisticated language (Strahl and Allis, 2000; Berger, 2007), and such a program is fundamental to normal development and disease pathogenesis (Margueron et al., 2005; Bhaumik et al., 2007).”
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, neutral): “Five K residues on the tails of histones H3 and H4 (H3K4, -9, -27, -36, and H4K20) as well as K79 located within the core of histone H3 have been shown to be sites for methylation ( Margueron et al., 2005; Zhang and Reinberg, 2001).”
Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer (2017, neutral): “These nuclear histones undergo various chemical modifications such as acetylation, methylation, ubiquitination, sumoylation, poly ADP-ribosylation, and phosphorylation [3].”
The mammalian epigenome. (2007, background): “By regulating chromatin structure and DNA accessibility, these chemical changes inﬂuence how the genome is made manifest across a diverse array of developmental stages, tissue types, and disease states (Bird, 2002; Goll and Bestor, 2005; Margueron et al., 2005).”
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. (2006, background): “Various observations suggest that chromatin undergoes important alterations during mammalian development (Delaval and Feil, 2004; Margueron et al., 2005; Sado and Ferguson-Smith, 2005).”
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (2006, background): “Trimethylation of lysine 4 of histone H3 (H3K4me3) is associated with active transcription (reviewed in Margueron et al., 2005).”