Childhood trauma associated with smaller hippocampal volume in women with major depression.

By M. Vythilingam, Christine Heim, Jeffrey Newport, Andrew H. Miller, Eric R. Anderson, Richard A. Bronen, M. Brummer, Lawrence W. Staib, Eric Vermetten, D. S. Charney and 2 more. American Journal of Psychiatry, 2002

836 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/2a82a192eee0ef4842359477b75e7e3ab502aa0f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Bruce S. McEwen
2. C. Nemeroff
3. Christine Marcelle Heim
4. Andrew H. Miller
5. Michael Joseph Meaney
6. A. Danese
7. Megan R. Gunnar
8. Terrie E. Moffitt

In Cellular and Molecular Neuroscience

1. Peter J. Gianaros
2. Wayne C. Drevets
3. Christine Marcelle Heim
4. Diego A. Pizzagalli
5. C. Nemeroff
6. A. Danese
7. E. Gould
8. Nicholas B. Allen

In Pharmacology

1. Bruce S. McEwen
2. Joseph L. Price
3. Maura L. Furey
4. Andrew H. Miller
5. D. Newport
6. Peter J. Gianaros
7. Diego A. Pizzagalli
8. Wayne C. Drevets

Citations in the corpus

• The role of the hippocampus in the pathophysiology of major depression. (2004, neutral): “These data are consistent with those from other studies that examined women who had a history of prepubertal abuse; in general, past abuse is associated with reduced HC volume.(24,81,82) Unfortunately, the samples of women studied to date have been heterogeneous with respect to past severity, durati”
• Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. (2016, background): “Reprinted with permission from the American Journal of Psychiatry. history of childhood maltreatment, but not in equally depressed women without ELS (Vythilingam et al., 2002), a finding confirmed by others (Buss et al., 2007; Frodl et al., 2010).”
• Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “Depressed patients with a history of childhood maltreatment showed smaller hippocampus than both depressed patients without a history of childhood maltreatment and non-maltreated/non-depressed individuals [125].”
• The neurobiology of stress and development. (2007, background): “…with this distinction, CRH-1 receptors are more abundant in cortico-limbic pathways that mediate fear and anxiety-related behaviors, whereas CRH-2 ANRV296-PS58-07 ARI 17 November 2006 1:24 receptors are found predominantly in subcortical brain regions (Sanchez et al. 2000, Vythilingam et al. 2002).”
• Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse (2009, background): “Childhood abuse in humans is associated with altered hippocampal developmen”
• Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity (2007, background): “Abnormal activity and structure in PFC and subcortical regions such as hippocampus and amygdala have been associated with the occurrence of environmental stressors (Teicher et al., 2003; Vythilingam et al., 2002).”
• Effects of Early Life Stress on Cognitive and Affective Function: An Integrated Review of Human Literature (2010, background): “Only a few studies have controlled for the presence of clinical disorders, or used nonclinical samples in order to attribute reductions in hippocampal volume to ELS (De Bellis et al. 2009; Vythilingam et al. 2002).”
• The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, background): “Reprinted from Vythilingam et al. (2002). Link between childhood trauma and depression: HPA axis studies in humans 699”