Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.

By J. Rejman, V. Oberle, I. Zuhorn, D. Hoekstra. Biochemical Journal, 2004

2,811 citations recorded by the source corpus.

Subfields: Biomaterials, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2a3263c7672b725a7b24734070b787aba4a0a3d1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Cell Biology

In Molecular Biology

Citations in the corpus

Physical approaches to biomaterial design (2009, methodology): “Regardless of the method of administration, particles larger than 500 nm can be phagocytosed by macrophages, and smaller particles can be endocytosed by professionally phagocytic or non-phagocytic cell”
Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. (2014, result): “agrees with previous observations that micron-sized nanoparticles show poor cellular uptake.(57) 59 These”
Nanocarriers’ entry into the cell: relevance to drug delivery (2009, methodology): “using 50–1000 nm PSt beads devoid of ligands [95].”
Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, positive): “In vitro studies of non-phagocytic cellular uptake of latex spheres have demonstrated slower uptake and processing of large spheres (>200 nm) relative to small ones (50 and 100 nm) [15].”
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. (2010, result): “05), which was in agreement with the previous results [10,30].”
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “Another report suggested that large particles (500 nm) are preferentially taken up through caveolae where they do not suffer lysosomal degradation (Rejman et al., 2004).”
Sol-gel based materials for biomedical applications (2016, background): “In order for a material to be taken up efficiently by nonphagocytic cells, for example, the particle size of the material needs to be on the sub-micron scale [400,406].”
Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. (2004, background): “Another recent report suggested that the sizes of delivered molecules could have a major impact on their method of internalization and further endocytic delivery [33].”