Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.
By Chunbai He, Yiping Hu, Lichen Yin, Cui Tang, C. Yin. Biomaterials, 2010
2,415 citations recorded by the source corpus.
Subfields: Biomaterials, Molecular Biology, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/b5fa4148f09d2f21c9d0e36269dc29052261e442
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In Pharmaceutical Science
Citations in the corpus
- Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Sterically-stabilized colloids with positive charges have also demonstrated enhanced tumor accumulation [102, 103] while others seem less efficacious [90, 91].”
- The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “In other systems, negatively-charged particles are recognized by the MPS more slowly than similar systems with positivelycharged surfaces [136,137], but their clearance remains faster than that of their neutral counterpart [136].”
- Engineered nanoparticles interacting with cells: size matters (2014, background): “polymer 150–500 L02, SMMC-7221 Fluorimetry Large NPs with high net charge: uptake more efficient [58]”
- Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence (2022, background): “They also affect their attachment, firm adhesion [15], phagocytosis [16], circulation half-life, cellular distribution [17], cellular uptake and endocytosis [18,19].”
- Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “Trop J Pharm Res, April 2013;12 (2): 268 Figure 2: Biodistribution of RhB-CMCNP of varying ZP and size in different parts of the body [17].”
- The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles (2011, positive): “The uptake profiles of PEG-CA8 NPs with various surface charges by the Kupffer cells in the liver are consistent with the results from the in vitro macrophage uptake studies, as well as some previous reports concerning the effect of surface charge on the macrophage uptake of inorganic NPs [9], dendr”
- Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, methodology): “Interestingly, worm-like particles with very high aspect ratios seem to exhibit negligible uptake by macrophages and have increased blood circulation [88,150,154].”
- Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “A similar trend was also observed in chitosan polymeric nanoparticles (He et al., 2010).”