A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

By D. Corti, Jarrod E. Voss, S. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. Vachieri, Debora Pinna, A. Minola, Fabrizia Vanzetta and 13 more. 2011

1,233 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Infectious Diseases

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Barney S. Graham
2. Michael B. Doud
3. M. Kanekiyo
4. F. Krammer
5. F. Sallusto
6. A. Tortoricia
7. David Veeslera
8. P. Palese

In Genetics

1. Michael B. Doud
2. Steven S. Ma
3. Andrew T. McGuire
4. Jesse D. Bloom

In Infectious Diseases

1. F. Krammer
2. A. Tortoricia
3. David Veeslera
4. Andrew T. McGuire
5. P. Palese
6. R. Koup
7. Jesse D. Bloom

Citations in the corpus

• Next-Generation Influenza Vaccines. (2020, background): “…1 subtypes (Okuno et al. 1993; Throsby et al. 2008; Ekiert et al. 2009; Sui et al. 2009), group 2 subtypes (Ekiert et al. 2011; Friesen et al. 2014), or across both group 1 and group 2 subtypes (Corti et al. 2011; Nakamura et al. 2013; Joyce et al. 2016; Kallewaard et al. 2016; Lang et al. 2017).”
• Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine (2016, neutral): “…antibodies have been identified, such as FI6v3 and 39.29, both of which derive from the HV3-30 germline gene; however, co-crystal structures with HA reveal different modes of recognition (Corti et al., 2011; Nakamura et al., 2013), and FI6v3 and 39.29 are thus not members of the same class.”
• Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages (2014, result): “This result confirms the important observation made previously that stem-directed MAbs are not exclusively of IGHV1-69 origin (3, 11) and further suggests that the repertoire of such stem MAbs is more diverse than previously known.”
• Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin (2016, background): “To answer this question, we examined the inherent mutational tolerance of the largely overlapping epitopes of four broadly neutralizing anti-stalk antibodies: F10 [35], CR6261 [36], FI6v3 [37], and CR9114 [38].”
• Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies (2013, background): “Stalk-specific antibodies that have cross-reactive and neutralizing activities against group 1 and group 2 HA-expressing viruses have been described previously (22, 23).”
• Structural insights into coronavirus entry (2019, background): “tralizing antibodies to this site could putatively prevent fusogenic conformational changes, as proposed for influenza virus hemagglutinin or HIV envelope (Corti et al., 2011; Kong et al., 2016; Lang et al., 2017).”