Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages
By J. Whittle, A. Wheatley, Lan Wu, D. Lingwood, M. Kanekiyo, Steven S. Ma, S. Narpala, Hadi M. Yassine, Gregory M. Frank, J. Yewdell and 6 more. 2014
232 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology
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In Epidemiology
- Barney S. Graham
- Kim-Marie A. Dam
- S. Ou
- Haoqing Wang
- Zhi Yang
- Pamela J. Bjorkman
- Alexander A. Cohen
- Jesse D. Bloom
In Immunology
- Kim-Marie A. Dam
- S. Ou
- Haoqing Wang
- Zhi Yang
- Pamela J. Bjorkman
- Alexander A. Cohen
- Priyanthi N P Gnanapragasam
- Kwinten Sliepen
Citations in the corpus
- Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages (2018, background): “glycans, are of the HV1-69 class (48), which is generally incompatible with the N38”
- Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations In Ovo (2018, methodology): “We used HAs that possess a Y98F substitution which prevents HA binding to sialic acid (29).”
- Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers (2020, background): “Y98F (H3 numbering), to abolish sialic acid binding [34] that could result in interactions of aggregation of HAs on neighboring particles.”
- Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine (2016, unknown): “, 2011, 2013) (Table S1A)—showed transient expansion of H1- and H5-cross-reactive memory B cells specific to the HA stem (Wheatley et al., 2015; Whittle et al., 2014).”
- Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines (2020, background): “All HA fusions to the I53_dn5B trimer contained full-length HA ectodomains including native secretion signals, and the H1 and H3 HAs contained an additional mutation (Y98F) to knock out sialic acid binding to facilitate expression and purification 73 .”