Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine

By M. Joyce, A. Wheatley, P. Thomas, Gwo-Yu Chuang, C. Soto, R. Bailer, A. Druz, Ivelin S. Georgiev, Rebecca A. Gillespie, M. Kanekiyo and 33 more. 2016

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Seyhan Boyoglu-Barnum
2. Daniel Ellis
3. M. Kanekiyo
4. Rebecca A. Gillespie
5. Barney S. Graham
6. Young-Jun Park
7. Geoffrey B. Hutchinson
8. M. Murphy

Citations in the corpus

• Next-Generation Influenza Vaccines. (2020, background): “Sequence analysis of individual B cells sorted by their ability to recognize conserved antigenic supersites combined with bioinformatic tools has identified several convergent multidonor B-cell lineages with desirable functional antibody properties that could serve as molecular end points for vaccin”
• Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem (2019, unknown): “Although the use of recombinant trimeric HA probes for ex vivo identification of HA-specific B cells by flow cytometry is well established (2, 11, 21), stem-specific B cell responses to seasonal observed during primary immunization also translates into a diminished capacity to recall stem-specific m”
• Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers (2020, unknown): “cellular cytotoxicity (ADCC) responses [3, 7-9].”
• Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses (2020, background): “The discovery in 1993 of the murine antibody C179 that targets the conserved HA stem and neutralizes multiple subtypes within group 1 influenza A viruses 41 and the subsequent discovery of multiple human bNAbs targeting the same stem region 10-15,20,45-48 have revealed the vulnerabilities of the HA ”
• Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines (2020, background): “We demonstrated the apparent epitope and angle of approach of a common class of vaccine-elicited, cross-reactive, polyclonal NHP antibodies are remarkably similar to human multi-donor V ​ H 6-1+D ​ H 3-3–class antibodies 56,57 ​ , the broadest and most potent stem-directed human bnAbs 51 ​ .”