Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

By F. Krammer, Natalie Pica, R. Hai, Irina Margine, P. Palese. 2013

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In Epidemiology

In Immunology

Citations in the corpus

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans (2014, background): “This concept has been clearly demonstrated in animal models (33, 34).”
Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines (2020, background): “Because of the subdominant nature and broader cross-reactive potential of epitopes in the HA stem, several antigen design efforts have focused on removing or obscuring the head domain to elicit improved stem-focused responses 26–32 .”
Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach (2019, methodology): “We selected mH13/BYam, mH5/BYam, and mH8/BYam as immunogens, since we expected three immunizations to be sufficient to redirect the antibody responses toward conserved epitopes based on our previous studies with cHA antigens (23, 26, 27, 45).”
Immune history profoundly affects broadly protective B cell responses to influenza (2015, positive): “One strategy which has proved effective in mouse and ferrets is sequential immunization with chimeric HA molecules containing the same HA stalk region, but widely disparate HA heads, thus inducing a targeted response to the HA stalk (46-48).”
A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection (2022, background): “Therefore, it is of great significance to extend the strategy of stem HA immunogen design in the development of the universal influenza B vaccine [13,14].”
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses (2020, background): “Thus, directing vaccine-induced antibody responses to the conserved stem region has been a major strategy for universal influenza vaccine development efforts [23] [24] [25] [26] [27] [28] .”
Next-Generation Influenza Vaccines. (2020, background): “For example, if HA stem-based vaccines using either chimeric molecules with exotic HA head domains (Krammer et al. 2013; Bernstein et al. 2020), headless HA stem trimers delivered as soluble proteins (Impagliazzo et al. 2015), or displayed on nanoparticles (Yassine et al. 2015; Corbett et al. 2019)…”
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages (2018, positive): “This strategy has elicited heterosubtypic 390 group 1 and group 2 protection in animal models (50-53).”