Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

By M. S. Chen, A. Huber, M. E. V. D. Haar, M. Frank, L. Schnell, A. Spillmann, F. Christ, Martin E. Schwab. Nature, 2000

1,522 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/29bfc892092e66eb1e0c2d5f3a825aec06cfc867

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In Cellular and Molecular Neuroscience

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Citations in the corpus

A microfluidic culture platform for CNS axonal injury, regeneration and transport (2005, background): “Cocultures with other cell types, such as oligodendrocytes or astrocytes will also help to investigate mechanisms of axonal injury and regeneratio”
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration (2001, background): “and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injur”
Plasticity of motor systems after incomplete spinal cord injury (2001, background): “CNS myelin contains several proteins that inhibit nerve fibre growth: Nogo-A/NI-250 (Ref”
White matter in learning, cognition and psychiatric disorders. (2008, positive): “Several proteins in myelin, Nogo-A [ 68 ,69], MAG [70] and OMgp [71,72], cause the tips of growing axons to collapse and stop growth toward its target [73,74].”
Glial inhibition of CNS axon regeneration (2006, background): “Subsequent identification of the putative antigen led to the discovery of Nogo”
Rho Signaling Pathway Targeted to Promote Spinal Cord Repair (2002, background): “This is explained in part by myelin-derived inhibition (Caroni and Schwab, 1988; McKerracher et al., 1994; Mukhopadhyay et al., 1994; Chen et al., 2000) and the formation of a glial scar expressing inhibitory molecules (Snow et al.”
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS (2003, background): “…protein kinases such as mitogen-and stress-activated protein kinase, mitogenactivated protein kinase-activated protein kinase 1b, and phosphorylase kinase can be inhibited by Y-27632 at high doses, this drug is a relatively specific ROCK inhibitor at low concentrations (Davies et al., 2000).”
A class of membrane proteins shaping the tubular endoplasmic reticulum. (2006, positive): “Perhaps, a small percentage of the reticulons acts in other cellular compartments, as has been reported for Rtn4a/NogoA acting on the plasma membrane to inhibit neurite outgrowth (Chen et al., 2000; GrandPre et al., 2000; Oertle et al., 2003b).”
Regenerating the damaged central nervous system (2000, background): “Recently, the gene for this inhibitor has been sequenced and named nogo”