A microfluidic culture platform for CNS axonal injury, regeneration and transport

By A. Taylor, Mathew Blurton‐Jones, S. Rhee, D. Cribbs, C. Cotman, N. Jeon. Nature Methods, 2005

1,128 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/ee7110dba45e442cc7387536710b26724218fe08

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In Biomedical Engineering

In Cellular and Molecular Neuroscience

Citations in the corpus

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death (2011, positive): “…direct addition of α-syn pffs to either neurites or somata leads to propagation of pathologic α-syn aggregates throughout the neuron, we utilized microfluidic culture devices which isolate the neuronal processes from the cell bodies via a series of interconnected microgrooves (Taylor et al., 2005).”
Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences (2017, background): “For example, in neuronal cell cultures where it is desirable to individually access the cell body and axonal processes, a simple fluidic design connecting a large channel (hundreds of micrometers wide) to a series of small channels (with widths of a few micrometers) oriented orthogonal to the large ”
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease (2009, methodology): “To further examine the effects of NSC-derived BDNF in vitro, we used a microfluidic cell culture device that greatly facilitates axonalspecific experimentation and analysis (24).”
c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration (2012, positive): “Microfluidic Chambers Using a three-compartment microfuidic chamber (Taylor et al., 2005), 5,000 adult DRG neurons were plated in the central compartment in defined medium with 50 mM glucose (Dong et al., 1999).”
Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “, 2010), the nervous system (Booth and Kim, 2012; Brown et al., 2014; Kerman et al., 2015; Nery et al., 2015; Park et al., 2009; Taylor et al., 2005), the pancreas (Silva et al.”