Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

By P. Dergham, B. Ellezam, C. Essagian, H. Avedissian, W. Lubell, L. Mckerracher. Journal of Neuroscience, 2002

718 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/4e1c37d0ccdb0720046efe80f8483d9b48398e89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Martin E. Schwab
2. G. Ferraro
3. L. Mckerracher
4. A. Fournier
5. J. Silver
6. Zhigang He
7. Glenn Yiu
8. A. Tran

In Developmental Neuroscience

1. Martin E. Schwab
2. G. Ferraro
3. L. Mckerracher
4. A. Fournier
5. Zhigang He
6. Glenn Yiu
7. J. Silver
8. Michael Chopp

In Pathology and Forensic Medicine

1. Martin E. Schwab

Citations in the corpus

• Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS (2003, background): “In the study by Dergham et al .”
• Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth (2012, positive): “MiR-133 also downregulates RhoA protein expression [37, 38], and since the inhibition of RhoA enhances regrowth of the corticospinal tract after spinal cord injury [39, 40], miR-133b appears essential for neurite outgrowth and functional recovery after spinal cord injury in adult zebrafish [21].”
• Rho signaling and axon regeneration. (2012, methodology): “correlated with the cells expressing high levels of active Rho, and the overall extent of tissue loss was reduced after treatment with Cethrin (Dergham et al., 2002; Lord-Fontaine et al., 2008).”
• Regeneration beyond the glial scar (2004, background): “CSPGs in the glial scar impair neuronal outgrowth by signalling through the Rho/ROCK pathway, and specific inhibition of Rho GTPase enhances process outgrowt”
• Glial inhibition of CNS axon regeneration (2006, background): “Inhibiting RhoA using C3 transferase or a dominant-negative approach also promotes axon outgrowth on inhibitory substrates, as can pharmacological inhibition of ROC”
• Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival. (2013, background): “…by use of drugs such as Y27632 or HA1077 promotes neurite outgrowth and blocks effects of neurite outgrowth inhibitors (Borisoff et al., 2003, Bertrand et al., 2005, Lingor et al., 2007) and promotes axon regeneration and sprouting following injury (Dergham et al., 2002, Chan et al., 2005).”
• The role of the Rho GTPases in neuronal development. (2005, background): “neurite outgrowth and growth cone collapse (Lehmann et al. 1999; Dergham et al. 2002; Niederost et al. 2002; Winton et al. 2002; Borisoff et al. 2003; Dubreuil et al. 2003; Fournier et al. 2003).”
• Nogo and axon regeneration. (2004, background): “The Rho-inactivating enzyme C3 transferase has been applied to optic nerve and spinal cord lesion sites [31,37,49], resulting in enhanced regenerative sprouting of retinal axons and CST fibres, and in more axons located distally from the lesion.”
• Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains (2006, neutral): “Other modifications to the BBB scale included elimination of paw position from the scale (Gilad and Gilad, 2001), adding categories for curled or flat toes (Dergham et al., 2002) and changing the definition of trunk control (Gilad and Gilad, 2001).”
• ROCKs: multifunctional kinases in cell behaviour (2003, background): “The inhibition of ROCKs also stimulates axon regeneration and recovery after spinal-cord injur”
• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Indeed, use of the specific inhibitors C3 coenzyme or Y-27632 in vivo facilitates axonal growth following SCI (90, 120, 268, 316).”