TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
By Li Yang, Yanli Pang, H. Moses. Trends in immunology, 2010
1,007 citations recorded by the source corpus.
Transforming growth factor β (TGF-β) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-β remain unclear. TGF-β exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-β enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-β regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor microenvironment causing direct changes in tumor cells. Understanding TGF-β regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-β antagonists and biomarkers for patient selection and efficacy of TGF-β antagonist treatment.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8ed818e349b88ab950275ca70d38454199423a1b
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In Immunology
In Molecular Biology
- Nikolaos G. Frangogiannis
- D. Hanahan
- R. Weinberg
- M. Dobaczewski
- David A. Baker
- Y. Hao
- A. Biernacka
- P. ten Dijke
Citations in the corpus
- TGF-β signaling in fibrosis (2011, background): “E-mail: nikolaos.frangogiannis@einstein.yu.edu implicated in a wide range of cell functions, critically regulating tissue homeostasis and repair, immune and inflammatory responses, ECM deposition, cell differentiation, and growth (Schiller et al. 2004; Yang et al. 2010).”
- Hallmarks of cancer: the next generation. (2011, positive): “For example, cancer cells may paralyze infil-trating CTLs and NK cells, by secreting TGF-b or other immuno-suppressive factors (Yang et al., 2010; Shields et al., 2010).”
- TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “Loss of tumor suppressor function and epigenome and microenvironmental changes can also affect the tumor-promoting activity of the TGF-β receptor/SMAD pathway [53].”