Effects of environmental enrichment on gene expression in the brain.

By C. Rampon, Cecilia H. Jiang, Helin Dong, Yanan Tang, David J. Lockhart, Peter G. Schultz, Joe Z. Tsien, Yinghe Hu. Proceedings of the National Academy of Sciences of the United States of America, 2000

629 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/282c1c58d803aa6d39127ce87a7aae3d96e9be84

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In Cancer Research

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Citations in the corpus

How Do Parents Support Preschoolers’ Numeracy Learning Experiences at Home? (2009, background): “Researchers have concluded that exposure to numeracy concepts (including number sense concepts) at home is important (Blevins-Knabe and Musun-Miller 1996; Huntsinger et al. 2000; LeFevre et al. 2009b, c, 2002; Pan et al. 2006 ).”
Enriched environments, experience-dependent plasticity and disorders of the nervous system (2006, background): “Many of these cellular changes are also consistent with enrichment-induced alterations in the expression of genes involved in synaptic function and cellular plasticit”
Lead neurotoxicity in children: basic mechanisms and clinical correlates. (2003, methodology): “High-density oligonucleotide microarrays were used to analyse gene expression in young adult mice raised in either enriched environments or in less stimulating conditions (Rampon et al., 2000).”
An Environmental Approach to Positive Emotion: Flowers (2005, background): “Environmental enrichment also is known to upregulate genes involved with neuronal growth (Rampon et al., 2000).”
Environmental enrichment and neurogenesis: from mice to humans (2015, methodology): “using microarrays and other genomic methods [24 ,25,26].”
Training-induced structural changes in the adult human brain. (2008, background): “At the behavioural level enrichment is associated with increased learning and memory and reduction in age-related memory decline [11,91,92,105].”
Structural plasticity associated with exposure to drugs of abuse. (2004, positive): “…estimated that over 90% of excitatory synapses are on dendritic spines, and synaptogenesis associated with experiences like learning or environmental complexity is reflected by changes in the number of dendritic spines (Greenough et al., 1990; Kolb et al., 1998; Woolley, 1999; Rampon et al., 2000).”
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder (2008, background): “Enrichment also results in molecular changes, including modulation of the genetic expression of neurotransmitter pathways, differential transcription of neurotransmitter-related target genes, and increased neurotrophic factors (Pham, Winblad, Granholm, & Mohammed, 2002; Rampon et al., 2000).”
Brain plasticity and behaviour in the developing brain. (2011, neutral): “% %Sorting% out%the%areal7dependent%critical%windows%will%be%a%challenge% for%the%next%decade.”
Anatomical and physiological plasticity of dendritic spines. (2007, background): “…by Lewis 2004, Leggio et al. 2005), enrichment enhances long-term potentiation (LTP) in the hippocampus (Duffy et al. 2001), affect gene expression (Rampon et al. 2000, Lazarov et al. 2005), cell proliferation and survival (Altman & Das 1964, Szeligo & Leblond 1977, van Praag et al. 1999),…”
Evolutionary Biology of Animal Cognition (2004, background): “…environmental enrichment exhibit better learning and memory and increased brain size, neuron size, dendritic branching, and synapses per neuron, as well as different expression of genes linked to neuronal structure, synaptic plasticity, and transmission (Rampon et al. 2000, van Praag et al. 2000).”
Genes and Ideologies (2008, background): “14 For more on this kind of gene-environment inter- action, see, e.g., McClearn 2004, Meaney 2001, Rampon et al. 2000, Kempermann et al. 1997.”