DNA methylation in health and disease

By Keith D. Robertson, A. Wolffe. Nature reviews genetics, 2000

1,115 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/28018fd22cdc893a86bcd1557604955493a10a9a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Polyploid formation in cotton is not accompanied by rapid genomic changes (2001, background): “Similarly, some epigenetic systems such as DNA methylation‐demethylation (Finnegan et al. 1998) may mediate genomic interactions through effects on ectopic recombination (Robertson and Wolffe 2000; Yoder et al. 1997), and also may be related to activation of quiescent mobile elements (Matzke and Mat”
DNA methylation and human disease (2005, background): “Reactivation of transposon promoters following demethylation might also contribute to aberrant gene regulation in cancer by TRANSCRIPTIONAL INTERFERENCE or the generation of antisense transcript”
DNA methylation profiles in monozygotic and dizygotic twins (2009, background): “In the last decade, however, evidence has been accumulating that epigenetic modifications of DNA and histones can have a primary role in phenotypic outcomes, including human diseas”
Choline: critical role during fetal development and dietary requirements in adults. (2006, neutral): “DNA methylation occurs at cytosine bases that are followed by a guanosine (CpG sites) (52) and influences many cellular events, including gene transcription, genomic imprinting, and genomic stability (60,64,105).”
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity (2002, background): “DNA methylation is a very active process in early development that is commonly associated with the inactivation of genes (Robertson and Wolffe, 2000).”
Early detection: The power and the promise of DNA methylation markers (2003, neutral): “Dense methylation of promoter regions is associated with a compacted chromatin structure, and accompanying transcriptional silencing of the affiliated gen”
Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b (2003, background): “A number of proteins, including PCNA, DMAP1, HDAC1, HDAC2, and pRB, have been shown to interact with Dnmt1 and may recruit Dnmt1 to highly methylated heterochromatin during the late S phase (38).”
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. (2002, background): “…a number of proteins capable of interacting with Dnmt1, Dnmt3a or Dnmt3b, including PCNA, DMAP1, HDAC1, HDAC2, pRB and RP58, have been identified (Robertson and Wolffe, 2000; Fuks et al., 2001; Bachman et al., 2001), their function in modulating DNA methyltransferase activity, targeting DNA…”
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis (2005, background): “Dnmt1 has been largely viewed as the maintenance enzyme, owing to its preference for hemimethylated DNA (2).”