Partners in transcription: NFAT and AP-1

By F. Macian, C. López-Rodríguez, Anjana Rao. Oncogene, 2001

814 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/2797761b1d0bf6883bb2056e048728a77196e4cd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. J. Avruch
2. S. Harrison
3. J. Kyriakis
4. Philippe P Roux
5. J. Blenis

In Molecular Biology

1. P. Hogan
2. Anjana Rao
3. J. Avruch
4. S. Harrison
5. T. Maniatis
6. P. Krammer
7. J. Kyriakis
8. J. Blenis

Citations in the corpus

• Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “It is clear that NFAT activates transcription of a large number of genes during an effective immune response (Rao et al. 1997; Kiani et al. 2000; Serfling et al. 2000; Macián et al. 2001).”
• Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer (2004, background): “For example, most composite NFAT–AP-1 regulatory elements contain nonconsensus AP-1 recognition elements (Chinenov and Kerppola, 2001; Macian et al, 2001).”
• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Various cytokine promoters, e.g., IL-2, IL-4, IL-5, IFN-γ, and TNF-α contain cooperative NFAT:AP-1 binding sites which greatly enhance transcription of the respective cytokine (Rao et al., 1997; Chinenov and Kerppola, 2001; Macian et al., 2001; Hermann-Kleiter and Baier, 2010).”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “This favors the cooperative binding and synergistic trans activation of numerous genes (IL-2, IL-4, IL-5, and CD40L are examples) (113, 184).”
• Transcriptional mechanisms underlying lymphocyte tolerance. (2002, neutral): “…(Fos/Jun), to inducecytes to self- and environmental antigens, in part by a large number of cytokine genes and other genes thatproducing immunosuppressive cytokines such as TGF are central to the productive immune response (Rao etand IL-10 (Maloy and Powrie, 2001). al., 1997; Macian et al., 2001).”
• CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, neutral): “AP-1/ATF factors also regulate important immune response genes, exemplified by their well-known cooperation with NFAT factors to induce cytokine gene expression (50).”