Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

By J. Eiserich, S. Baldus, M. Brennan, Wenxin Ma, Chunxiang Zhang, A. Tousson, L. Castro, A. J. Lusis, W. Nauseef, C. White and 1 more. Science, 2002

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How researchers see this paper

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Myeloperoxidase: friend and foe (2005, neutral): “dependent signaling [111].”
Peroxynitrite, a Stealthy Biological Oxidant* (2013, background): “It is important to note that, during vascular inflammation, neutrophil degranulation of myeloperoxidase also contributes to protein tyrosine nitration processes by peroxynitrite-independent mechanisms (51, 74).”
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies (2004, background): “Increasing attention is being focused on the possible roles of MPO in atherosclerosis and other inflammatory disease”
Reactive Oxygen Species in Cardiovascular Disease (2011, background): “In addition to producing reactive chlorinating species in humans, MPO catalyzes the oxidation of NO in human plasma in a manner that can reduce the bioavailability of NO [147, 148].”
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. (2004, background): “Colocalization of these peroxidases with NT strongly indicates this reaction is the primary source of tyrosine nitration in vivo (26).”
Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, positive): “Myeloperoxidase seems to modulate vascular signaling and vasodilatory function of NO, linking the fight against infection with metabolic events (314).”