Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

By R. Yamamoto, Yohei Morita, Jun Ooehara, Sanae Hamanaka, M. Onodera, K. Rudolph, H. Ema, H. Nakauchi. Cell, 2013

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Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (2015, background): “…and unexplained heterogeneity within hematopoietic compartments calls for new approaches to complement our current models of blood and immune system development (Arinobu et al., 2007; Levine et al., 2015; Murre, 2007; Pronk et al., 2007; Schroeder, 2010; Wilson et al., 2008; Yamamoto et al., 2013).”
Mapping Transcriptomic Vector Fields of Single Cells (2022, positive): “Notably, we found that the developmental F-LAP for the differentiation of HSC to Meg lineage requires the least time [roughly 31 h, in line with what reported in (Yamamoto et al., 2013)], further corroborating the observation of the early appearance of Meg lineage (Figures 6E and S7D).”
Human haematopoietic stem cell lineage commitment is a continuous process (2017, neutral): “For instance, unipotent progenitors can derive directly from HSCs without proceeding through oligopotent progenitors 14,15 and lineage commitment was observed in progenitors proposed to be oligopotent 7,10,16 .”