REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders

By M. Gershon, J. Tack. 2007

1,493 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/26da2d8e63f3d03d69da48b9731480904f9f13ba

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Citations in the corpus

Serotonin, serotonin receptors and their actions in insects (2014, background): “Approximately 80-90% of the human body’s total 5-HT is located in the enterochromaffin cells of the gut, where it is used to regulate intestinal motility ([32,33]).”
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “Serotonin The serotonin pathway is one of the core signaling pathways in the gut (Gershon and Tack, 2007; Lesurtel et al., 2008).”
Handbook of the behavioral neurobiology of serotonin (2010, background): “The serotonergic neurons are located in the midbrain reticular formation, and have extensive axonal branching throughout the neuroaxis ( Azmitia and Segal, 1978 ; Azmitia and Gannon, 1983 ) and the gut enterochromaffin cells and myenteric plexus ( Gershon and Tack, 2007 ).”
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis (2015, unknown): “In the GI tract, 5-HT is synthesized by specialized endocrine cells, called enterochromaffin cells (ECs), as well as mucosal mast cells and myenteric neurons (Gershon and Tack, 2007), but the functions of these different pools of gut 5-HT are incompletely understood.”
Stress & the gut-brain axis: Regulation by the microbiome (2017, unknown): “Supporting this idea, drugs that modulate serotonergic neurotransmission, such as tri-cyclic antidepressants and speci ﬁ c serotonin reuptake inhibitors, also have ef ﬁ cacy for treating irritable bowel syndrome (IBS) and other GI disorders (Creed, 2006; Gershon and Tack, 2007).”
Neurotransmitter modulation by the gut microbiota (2018, background): “While serotonin is broadly used throughout the body, 90–95% of serotonin resides in the gastrointestinal tract, mostly in epithelial enterochromaffin cells (ECs)(Gershon and Tack, 2007).”
Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine (2014, unknown): “…in light of the critical role serotonin plays as a signaling molecule in the enteric nervous system (Mayer, 2011; Ormsbee and Fondacaro, 1985), where modulation of the serotonin receptors has been proposed as a treatment for irritable bowel syndrome (Gershon and Tack, 2007; Mawe et al., 2006).”
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “The role of EC cell-derived serotonin in modulating gastrointestinal (GI)motility has beenwell described (1).”
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, background): “Whereas brain-derived serotonin is implicated in cognitive functions (Heath and Hen, 1995), the function(s) of gut-derived serotonin (GDS), which accounts for 95% of total serotonin, is still a matter of debate (Gershon and Tack, 2007).”
The Expanded Biology of Serotonin (2009, unknown): “In the central nervous system (CNS), serotonin is almost exclusively produced in neurons originating in the raphe nuclei located in the midline of the brainstem.”
Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “Whilst serotonergic signalling is critical in CNS and ENS function, a full review is not within the scope of this article (See (Gershon and Tack, 2007; Mawe and Hoffman, 2013; O’Mahony et al., 2015; Spiller, 2008) for excellent reviews on this topic).”