Mild cognitive impairment represents early-stage Alzheimer disease.

By J. Morris, M. Storandt, J. Miller, D. McKeel, Joseph L. Price, E. Rubin, L. Berg. Archives of Neurology, 2001

1,851 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/25fa3656416076d80d786cb64819b30e3632cb37

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Citations in the corpus

Frequency and course of mild cognitive impairment in a multiethnic community (2008, methodology): “In addition to the type of cohort, the other key methodological factors differing across studies of MCI include: (1) whether MCI diagnoses are assigned on a case-by-case basis in a consensus conference of expert clinicians or assigned purely objectively using neuropsychological, functional, and medi”
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals (2008, background): “Many of these CDR = 0.5 individuals would be classiﬁed as having mild cognitive impairment in other settings (Morris et al. 2001; Storandt et al. 2006).”
Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging. (2004, neutral): “studies (Berg et al., 1998; Morris et al., 2001 ).”
Screening for Dementia in Primary Care: A Summary of the Evidence for the U.S. Preventive Services Task Force (2003, background): “Screening will also result in the detection of persons with MCI, a newly recognized condition that increases the risk of developing dementia.(105) No well-conducted RCT, however, provides information about an effective treatment for such individuals.”
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. (2003, background): “Impaired memory andBDNF in hippocampal neurons is significantly impaired hippocampal function is present in many human disor-when val66 in the proBDNF sequence is replaced with ders, including Alzheimer’s disease (Morris et al., 2001),a met.”
Multimodal Classification of Alzheimer’s Disease and Mild Cognitive Impairment (2011, methodology): “, 2009), hypometabolismmeasured by functional imaging (De Santi et al., 2001; Morris et al., 2001), and quantification of specific proteins measured through CSF (Bouwman et al.”
Clinical biomarkers in drug discovery and development (2003, background): “For example, poor correlations can be found between early biomarkers and gold-standard neuropsychiatric assessments during the early stages of neurodegenerative diseases such as Alzheimer's disease, in which the disease can progress asymptomatically for many year”
Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease. (2005, background): “A separate process, ubiquitous in aging, affects brain white matter with an anteriorto-posterior gradient and may underlie the executive difficulties common in aging.”
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002, background): “Studies defining MCI as an isolated amnestic syndrome have reported “conversion” of MCI subjects to AD at the approximate rate of 12 to 15% per year.(28) However, it is not known if all clinical MCI cases will eventually convert to AD.”
Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players (2005, background): “Although head trauma has been linked to irreversible cognitive deficits ( 24 , 29, 30), its role in causing eventual MCI or AD is less clear.”