Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

By Steven DeKosky, M. Ikonomovic, S. Styren, L. Beckett, S. Wisniewski, David A. Bennett, E. Cochran, J. Kordower, E. Mufson. Annals of Neurology, 2002

689 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/71fb7ca3230e3d3dbdaf8b5d52644cf22ca7bdb7

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Citations in the corpus

Mild cognitive impairment as a clinical entity and treatment target. (2005, methodology): “Moreover, the neurobiological phenotype of this subset of MCI represents a biological substrate that is intermediate between physiological changes of aging and fully developed AD: overrepresentation of the apolipoprotein E4 allele,(21,22) volumetric loss in entorhinal cortex and hippocampus as measu”
The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development (2003, background): “In addition, DeKosky and colleagues (DeKosky et al., 2002) failed to detect any reduction in ChAT activity in a number of cortical regions studied in patients diagnosed with MCI or mild AD, and in fact, activity was actually up-regulated in the frontal cortex and hippocampus of those with MCI.”
A network dysfunction perspective on neurodegenerative diseases (2006, background): “For example, choline-acetyltransferase activity in the hippocampus is increased in mild cognitive impairment (MCI), which may precede or represent early AD, but is decreased in later stages of the diseas”
Mild cognitive impairment (2006, background): “In one study using a common silver stain to identify classic neuritic plaques and neurofibrillary tangles, all people with MCI proximate to death had some evidence of the pathology of Alzheimer’s disease and nearly 40% met accepted pathologic criteria for Alzheimer’s disease [53].”
Brain imaging in Alzheimer disease. (2012, background): “This phenomena may reflect cholinergic or other neurotransmitter up-regulation (DeKosky et al. 2002), aberrant sprouting of cholinergic fibers (Masliah et al. 2003), inefficiency in synaptic transmission (Stern et al. 2004), increased calcium influx, and evidence of excitotoxicity (Palop et al.…”
The Neuropathology of Probable Alzheimer's Disease and Mild Cognitive Impairment (2009, background): “Studies of the pathologic basis of MCI have shown AD type pathology, including amyloid plaques, neurofibrillary tangles, and changes in choline acetyltransferase activity.(18) Although these studies have noted non-AD (eg, infarcts, cortical Lewy body disease) and mixed pathologies, a role in nonamne”
Religious Orders Study: Overview and Change in Cognitive and Motor Speed (2004, background): “Despite these structural and functional changes in the major cholinergic projection system, we found that the activity of cholinergic enzymes in the neocortex (Dekosky et al., 2002) and hippocampus (Ikonomovic et al.”
The Basal Forebrain Cholinergic Projection System in Mice Neuron Types in the Basal Forebrain - Chapter 28 The Mouse Nervous System (2012, background): “Postmortem studies have shown that mild AD is associated with preserved cortical ChAT activity (DeKosky et al., 2002).”
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. (2004, background): “These same functions seem to be most impacted in preclinical and early AD [10,26,28,40,62,81,130].”
EEG dynamics in patients with Alzheimer's disease. (2004, background): “A recent study found significant theta power differences during haptic tasks between healthy controls and MCI subjects (Grunwald et al., 2002), suggesting that activation paradigms in EEG studies can increase the sensitivity for cases at risk of developing AD.”