The six hyaluronidase-like genes in the human and mouse genomes.

By A. Csoka, G. Frost, R. Stern. Matrix Biology, 2001

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Hyaluronan as an Immune Regulator in Human Diseases (2011, neutral): “(68), and the mouse gene is on chromosome 9 (66).”
Hyaluronan in tissue injury and repair. (2007, background): “HYAL1 is also present in human serum (Csoka et al. 2001) and urine (Csoka et al. 1997).”
Glycosaminoglycans and their proteoglycans: host‐associated molecular patterns for initiation and modulation of inflammation (2006, background): “HA-degrading enzymes include both mammalian hyaluronidases (103), and bacterial hyaluronidases (104).”
Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions (2013, background): “ably secreted by the cell, while the smaller isoform is retained in acidic intracellular vesicles [46].”
The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. (2007, background): “Hyal1 and Hyal2 are the major hyaluronidases expressed in human somatic tissues (Csoka et al., 2001).”
Hyaluronic Acid in the Third Millennium (2018, background): “Both HYAL-1 and HYAL 2 have an optimal activity at acidic pH (≤4) [103,104] and are highly expressed in human somatic tissues [102].”
Hyaluronan: from extracellular glue to pericellular cue (2004, background): “Hyaluronan is cleaved by enzymes known as hyaluronidases; in humans, there are six hyaluronidase genes, which encode hyaluronidases that have different properties and cellular location”