Tumor stroma and regulation of cancer development.
By Thea D. Tlsty, Lisa M. Coussens. Annual Review of Pathology, 2006
1,019 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/24e12a7a16d05d489cbf97553282f44ebcc36a5f
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Citations in the corpus
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. (2010, background): “Although tumorigenesis has classically been viewed as a largely cell-autonomous process involving genetically transformed cancer cells, the importance of stromal cell types populating the neoplastic microenvironment is now well accepted (reviewed in Bissell and Radisky, 2001; Hanahan and Weinberg, 2”
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1 (2009, methodology): “The micrographs at higher magnification show the stained peritumoral stroma region (1) and a cancer nest (2).”
- Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Niches in Disease: Cancer Stem Cell Niches There is abundant evidence that the normal cells that surround and infiltrate tumors secrete factors that promote the growth and progression of cancer (Tlsty and Coussens, 2006).”
- Tumor self-seeding by circulating cancer cells (2009, background): “Promotion of Tumor Growth and Stroma Recruitment by Self-Seeding Aggressive cancer cells may promote tumor growth through the release of paracrine signals that enhance tumor angiogenesis and the recruitment of a supportive stroma (Carmeliet, 2005; Coussens and Werb, 2002; Joyce and Pollard, 2009; Ti”
- Supervised risk predictor of breast cancer based on intrinsic subtypes. (2009, methodology): “Thus the ROR predictor based on subtypes provides similar information as the OncotypeDx Recurrence Score for patients with ER-positive, node-negative disease.(4,5) Furthermore, the PAM50 assay provides a ROR score for all patients, including those with ER-negative disease, and is highly predictive o”
- Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, neutral): “While such effects are reflective of typical leukocyte activities ascribed to repair of tissue damage (Dvorak et al., 2011; Tlsty and Coussens , 2006), the chronic presence of paracrine and juxtacrine mitogenic signaling molecules provided by IICs can supply evolving neoplastic cells with signals…”
- Stromal gene expression predicts clinical outcome in breast cancer (2008, background): “These changes may include the recruitment of immune and endothelial cells providing growth and matrix remodeling factors, as well as a new blood supply promoting tumor growth and metastasi”
- Environment-mediated drug resistance: a major contributor to minimal residual disease (2009, result): “Tumour–stroma coalition The influence of stromal cells on tumour survival is often seen as the result of a passive relationship, but recent data have demonstrated that this relationship is more complex than previously though”
- Cells of origin in cancer (2011, background): “In addition, extrinsic mechanisms may be involved in generating tumour heterogeneity, because interactions between tumour cells and the stromal micro-environment are a crucial determinant of malignant growt”
- Matrix MetalloProteinases (MMPs) andTissue Inhibitors of MetalloProteinases (TIMPs): positive and negative regulators intumor cell adhesion (2010, neutral): “Matrix remodeling in cancer is primarily caused by MMP activity and this process is essential for solid tumors to progression [47–49].”