Environment-mediated drug resistance: a major contributor to minimal residual disease

By M. Meads, Robert A. Gatenby, W. Dalton. Nature Reviews. Cancer, 2009

861 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/35731a51218db6deff76e66a03e69b7a3a2a012f

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In Immunology

K. Polyak

In Oncology

Citations in the corpus

CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, neutral): “Among them, IL-6 and IL-8 have been reported to mediate CSCs enrichment and chemoresistance (Meads et al., 2009).”
Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “Notably, MRD in several kinds of cancers is enriched in CSCs, leading to intra-tumoral heterogeneity and poor prognosis [1, 9, 10, 37].”
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth (2015, background): “categorized the roles of CAFs in drug resistance, that is, in soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR) [98].”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Considering that compared with total circulating RNAs, exosomes typically target specific cells, detection of exosomal miRNAs in clinical examination appears reasonable, which might assist physicians with predicting cancer prognosis [82].”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “De novo and acquired resistance to chemo-, radiation, and targeted therapies remains a major stumbling block in cancer treatment [132].”
Intratumor heterogeneity: the Rosetta stone of therapy resistance (2020, background): “While the impact of microenvironmentally mediated resistance on relapse remains unclear (as tumor cells remain sensitive outside of the borders of protective niches), the phenomenon likely contributes to residual disease, providing reservoir of tumor cells capable of developing cell-autonomous resis”
Fibroblast heterogeneity in the cancer wound (2014, background): “Environment-mediated drug resistance can be further categorized into two major groups: soluble factor–mediated drug resistance and cell adhesion–mediated drug resistance (Meads et al., 2009).”