Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies

By K. Powers, M. Palazuelos, B. Moudgil, S. Roberts. 2007

357 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Materials Chemistry, Pollution

View Paper: https://www.semanticscholar.org/paper/24cc474cfa4934ab088e6b76ce6a0fddb6cbe6f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Nicole Riemer
2. Matthew West
3. Vyom Sharma
4. A. Dhawan
5. G. Oberdörster

In Materials Chemistry

1. Vyom Sharma
2. A. Dhawan
3. N. El-gendy
4. S. Jin
5. P. Biswas
6. Jingkun Jiang
7. M. Forrest
8. Yumei Xie

In Pollution

1. Vyom Sharma
2. A. Dhawan
3. Hans Bouwmeester

Citations in the corpus

• Review of health safety aspects of nanotechnologies in food production. (2009, background): “, composition, purity), characterization of NPs in biological matrices is more complex from an analytical point of view but also regarding lack of knowledge on which characteristics that need to be identified (Powers et al., 2007).”
• Quantitative characterization of nanoparticle agglomeration within biological media (2012, unknown): “One outcome of the many studies performed over the past decade is a requirement for an appropriate characterization of the nanoparticles before in vitro investigation to allow for correlative or evaluative studies (Gil et al. 2010; Powers et al. 2006, 2007; Warheit 2008).”
• Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, background): “They proposed key characteristics that should be evaluated and reviewed analytical methods of measuring nanomaterial size and shape, dispersion, physicochemical properties, surface area, porosity, and surface [14].”
• Toxicity assessment of nanomaterials: methods and challenges (2010, methodology): “Though the merit of this method lies in the fact that it provides two parameters simultaneously (size as well as surface area), it does have a pitfall in that it assumes a monodisperse system of average-sized spheres, so it does not account for the size distribution of the particles, which is a key ”
• Magnetic nanoparticles for theragnostics (2009, background): “Physiochemical characteristics of nanoparticles (size, shape, surface chemistry, solubility) each influence their toxic potential [104].”
• Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies (2009, background): “These changes may have a significant impact on observed toxicological responses (Powers et al. 2007).”
• Risk-based classification system of nanomaterials (2009, background): “Even though nanomaterial size is believed to be a factor influencing toxicity, there is little specific information available characterizing toxic effects relative to the 1–100 nm size range ( Powers et al. 2007 ).”
• Acute and chronic toxicity of nano-scale TiO2 particles to freshwater fish, cladocerans, and green algae, and effects of organic and inorganic substrate on TiO2 toxicity (2009, background): “…relationship between environmental exposure levels and toxicological effects levels for aquatic organisms have been particularly constrained by difficulties in measuring nanoparticles in environmental media and quantification of important toxicological characteristics (e.g., Powers et al. 2007).”
• Not ready to use – overcoming pitfalls when dispersing nanoparticles in physiological media (2008, background): “Due to the enormous colloidal polydispersity, size characterization constitutes in itself another major pitfall (Powers et al. 2007).”
• Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations (2014, unknown): “responds to, distributes, and eliminates the materials [15].”
• Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems (2023, background): “In essence, the size and surface area of these particles contribute to the rate at which these nanoparticles are endocytosed, distributed, retained, and eliminated within biological systems [76].”
• Aerosol Mixing State: Measurements, Modeling, and Impacts (2019, background): “Using a two-dimensional image, gives rise to the possibility of misinterpretations (Powers et al., 2007).”