Metal-induced oxidative stress and signal transduction.

By S. Leonard, G. Harris, Xianglin Shi. Free Radical Biology & Medicine, 2004

668 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/243b634cbfd22d4f4e13207d322bfbc5c3b42be1

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In Cancer Research

1. K. Rahman
2. M. Valko
3. M. Mazúr
4. G. Barrera
5. J. Telser

In Molecular Biology

1. M. Valko
2. K. Rahman
3. A. Hartwig
4. C. Wood
5. A. Farrell
6. A. Bhaduri
7. D. Beyersmann
8. M. Mazúr

Citations in the corpus

• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “In general, breast cancer stem cells display an upregulation of ROS-scavenging molecules that maintain ROS levels to be low, thereby contributing to tumor radioresistance.”
• Arsenic exposure and toxicology: a historical perspective. (2011, background): “…alter signal transduction, which leads to activation or inhibition of transcription factors, regulatory proteins which bind to DNA and regulate gene transcription (Bode and Dong, 2002; Druwe and Vaillancourt, 2010; Huang et al., 2004; Kumagi and Sumi, 2007; Leonard et al., 2004; Platanias, 2009).”
• Biological activity of vanadium compounds (2006, background): “1 Potential vanadium-induced cellular oxidative stress (see [16, 21]); SOD – superoxide dysmutase.”
• Oxidative Stress and Antioxidant Defense (2012, background): “Some metals, such as arsenite, induce ROS formation indirectly by activation of radical producing systems in cells.(56) Arsenic is a highly toxic element that produces a variety of ROS, including superoxide (O2 2), singlet oxygen ((1)O2), peroxyl radical (ROO ), nitric oxide (NO ), hydrogen peroxide”
• Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, neutral): “mutation, and tumour [128].”
• Antioxidant enzyme responses of plants to heavy metal stress (2012, background): “A growing amount of data provide evidence that metals are capable of interacting with nuclear proteins and DNA causing oxidative deterioration of biological macromolecules (Leonard et al. 2004).”
• Morphological, physiological and biochemical responses of plants to nickel stress: a review. (2013, neutral): “Heavy metals as well as Ni have capacity to create the OH by Haber/Fenton-Weiss reaction (Kehrer, 2000) but due to high reduction/oxidation capacity, Ni was not observed as a catalyst in this reaction (Leonard et al., 2004).”
• Zinc-induced Cell Death in Rice (Oryza Sativa L.) Roots (2005, background): “It is generally accepted that the ROS such as H2O2 activates members of the MAPK family.”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “signal cascades involving mitogen-activated protein kinases (MAPKs) and transcription factors AP-1 and NF B (Leonard et al. 2004).”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “…radicals, or non-redox metals, due o their ability to bind to critical thiols, have been impliated in the mechanisms of carcinogenesis and ageing Leonard et al., 2004; Pourahmad & O’Brien, 2001; Roy Saha, 2002; Santos et al., 2005; Stayner, Dankovic, & emen, 1996; Valko et al., 2005; Waalkes,…”
• Studies on free radicals, antioxidants, and co-factors (2007, background): “The iron under certain circumstances, can participate in the Fenton reaction, generating the highly reactive hydroxyl radical (Leonard et al 2004) which if produced in vivo, can react close to its site of formation hence causing localized damage.”
• ROS and ROS-Mediated Cellular Signaling (2016, background): “The MAPKKK in JNK pathway includes MEKK1, MEKK2, MEKK3, and MEKK4, MLK, and ASK1 and MAPKK contain MKK4, MKK3, MKK6, and MKK7 [62, 63].”
• Differential biochemical responses of wheat shoots and roots to nickel stress: antioxidative reactions and proline accumulation (2008, background): “Despite being a transition metal, Ni possesses only moderate redox activity due to its relatively high oxidation/reduction potential (Leonard et al. 2004).”
• Homeostasis and toxicology of essential metals (2012, background): “In mammals, one of the most important mechanisms of Ni toxicity is the induction of superoxide radicals (Kasprzak, 1987; Eisler, 1998; Lloyd and Phillips, 1999; Denkhaus and Salnikow, 2002; Leonard et al., 2004).”