Allergy, parasites, and the hygiene hypothesis.

By M. Yazdanbakhsh, P. Kremsner, R. van Ree. Science, 2002

1,585 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/23b4e39b92b65a43ab36672b3b248b1430c592c6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. Rick M. Maizels
2. M. Greaves

In Immunology

1. S. Galli
2. M. Tsai
3. O. Joffre
4. M. Nolte
5. R. Spörri
6. Rick M. Maizels
7. C. Reis e Sousa
8. K. Mills

In Physiology

1. S. Galli
2. M. Tsai
3. Rick M. Maizels
4. M. Wilson
5. M. Greaves
6. A. Khoruts
7. Edward J. Pearce
8. T. Borody

Citations in the corpus

• Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, background): “Mechanisms behind these adaptations are not simple and include the regulation of T cells and the balance between proand anti-inflammatory cytokine composition (10, 13).”
• Resilience and mental health. (2010, neutral): “…propose that effective mental resilience requires an individual homeostatic balance between negative and positive experiences, just as immune activation and suppression are proposed to balance in the modern hygiene hypothesis (Yazdanbakhsh et al., 2002; this is discussed further under challenge 1).”
• Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “Alterations of the gut microbiota disrupt this balance, resulting in the deregulation of immune responses that can promote a variety of disease outcomes (Wills-Karp et al., 2001; Yazdanbakhsh et al., 2002; Rautava et al., 2004; Rook and Brunet, 2005; Penders et al., 2007b; Shen et al., 2014).”
• Regulatory T cells: friend or foe in immunity to infection? (2004, background): “Furthermore, there is evidence that the incidence of atopic diseases (such as allergy and asthma) and autoimmune diseases is lower in individuals infected with helminth parasites or exposed to microbial products as childre”
• Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. (2014, background): “IL-4 is a typical Th2 cytokine with decisive significance in regulating Th1/Th2 cytokine balance (Paul and Seder, 1994; Yazdanbakhsh et al., 2002).”
• Fecal microbiota transplantation and emerging applications (2012, background): “However, not all gut microbial species are dependent on host health, and relationships with these microbes can become problematic”
• Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, positive): “This conclusion has been supported by studies of Th2 cell–inducing human helminth infections, in which both observational and posttherapy data show an inverse association between chronic infection and overt allergic responsiveness (16, 17).”
• Infection, immune responses and the aetiology of childhood leukaemia (2006, background): “An essentially similar immunological argument is embodied in the 'hygiene hypothesis' for childhood allergie”
• Homage to Linnaeus: How many parasites? How many hosts? (2008, background): “This provides a viable explanation for why allergies are much more common in human societies that have successfully reduced their parasite loads than in those that still bear a significant burden of parasitic helminths (60).”
• Immune Regulation by helminth parasites: cellular and molecular mechanisms (2003, background): “Because T H 2-inducing helminths (see later) are associated with the inhibition of T H 2-mediated inflammatory disease, mechanisms involving non-T H 1-cell populations, such as regulatory T (T Reg ) cells, are now being considere”
• Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. (2007, background): “Helminthic infections that intensely induce TH2 cytokines and IgE synthesis protect IgE-sensitized infants from atopic diseases.(30,31) Likewise, probiotics seem not to affect sensitization per se but regulate the path from sensitization to clinical disease, thus, as this study shows, increasing the”
• Helminth parasites – masters of regulation (2004, background): “These findings laid the basis for a new regulatory hypothesis, in which a helminthinduced regulatory network dampens responses to allergens (16, 187, 189, 190).”