Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

By T. Simoncini, A. Hafezi-Moghadam, D. Brazil, Klaus Ley, W. Chin, J. Liao. Nature, 2000

1,469 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/23836d1842d7476f4344d77aeba9dab97bacb4b4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Bart Staels

In Genetics

1. S. Manolagas
2. Mitchell Dowsett
3. Jan-Ake Gustafsson
4. T. Mak
5. Stephen Honig
6. P. Rackoff

In Molecular Biology

1. R. Jilka
2. N. Hynes
3. S. Kousteni
4. M. Marino
5. P. Galluzzo
6. P. Ascenzi
7. J. Liao
8. Bart Staels

Citations in the corpus

• ERBB receptors and cancer: the complexity of targeted inhibitors (2005, background): “and ER directly interacts with the p85 regulatory subunit of PI3”
• Principles for modulation of the nuclear receptor superfamily (2004, background): “For example, we have just begun to recognize the importance of the so-called NON-GENOMIC ACTION of nuclear receptor ligand”
• Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. (2004, background): “In vitro, administration of hepatocyte growth factor induces cellular proliferation via activation of the PI3K pathway (6), and hepatocyte cell lines that activate PKB/Akt resist apoptosis (7).”
• Sex steroids and bone. (2002, background): “Activation of PI3K results from direct interaction of the ER with the p85 regulatory subunit of the PI3K and is independent of the transcriptional activity of the receptor (Simoncini et al., 2000).”
• The role of nitric oxide in cancer (2002, background): “Recently several studies have shown that the oestrogen/oestrogen receptor complex binds to the p85a regulatory subunit of phosphatidylinositol-3-OH kinase (PI-(3)K), which leads to activation of protein kinase B/Akt [26], [27].”
• Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “Because Akt, in turn, phosphorylates and activates eNOS, statins can also increase eNOS activity through the PI3K/Akt pathway [78].”
• Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. (2005, background): “regulatory subunit of PI3-kinase (54) and Shc (55).”
• Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor α at the Plasma Membrane (2003, background): “This receptor has also been implicated in prevention of the inflammatory response to muscle ischemia-reperfusion injury (40), maintenance of the endothelial cell cytoskeleton, and upregulation of vascular cell migration and angiogenesis (33).”