ERBB receptors and cancer: the complexity of targeted inhibitors

By N. Hynes, H. Lane. Nature Reviews. Cancer, 2005

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Novel anticancer targets: revisiting ERBB2 and discovering ERBB3 (2009, background): “jpg" NDATA ITEM> ]> Members of the epidermal growth factor family of transmembrane receptors (Erbb family) are potent mediators of normal cell growth and developmen”
ErbB receptors and signaling pathways in cancer. (2009, background): “Intracellular pathways downstream of ErbB receptors ErbB receptors control key intracellular pathways that govern fundamental cellular processes including proliferation, cell migration, metabolism, and survival [1,21].”
The molecular biology of head and neck cancer (2011, background): “shtml?what=graphic&jpg=on&pathway_id=erbb1_receptor_proximal_pathway">EGFR seems to be crucial in squamous cells and signals through the Ras–MAPK, PI3K–PTEN–AKT and phospholipase C pathway”
Recent progress in tumor pH targeting nanotechnology. (2008, background): “In clinical setting, additional tumor microenvironmental factors such as epidermal growth factor, fibroblast growth factor, insulin-like growth factor, and extracellular matrix components are strongly associated with survival mechanisms of cancer cells under cytotoxic drug treatment [37-40].”