Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes.

By L. Björnström, M. Sjöberg. Molecular Endocrinology, 2005

1,408 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a350878a7b8ba19a1bb2c87049fe9e572812e2c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Mitchell Dowsett
2. Jan-Ake Gustafsson
3. S. Taube
4. I. Weaver
5. Lisa M. McShane
6. M. Szyf
7. Michael Joseph Meaney

In Molecular Biology

1. Michael Joseph Meaney
2. Lisa M. McShane
3. M. Szyf
4. M. Marino
5. P. Galluzzo
6. P. Ascenzi
7. Ruth Feldman
8. A. Masten

In Oncology

1. Jan-Ake Gustafsson

Citations in the corpus

• The different roles of ER subtypes in cancer biology and therapy (2011, background): “They can also interact and modulate the activity of one another, alter the activity of other transcription factors and participate in separate membrane or cytoplasmic signalling cascade”
• Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring (2006, background): “ER is a ligand-activated transcription factor that regulates gene transcription in response to estrogens (14, 15).”
• American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). (2010, background): “Estrogen signaling occurs via the standard classical steroid receptor mechanism.(11) Estrogen freely diffuses through the cellular membrane and binds monomeric ER protein, which seems to be almost exclusively nuclear even in the absence of ligand.”
• Estrogen synthesis and signaling pathways during ageing: from periphery to brain (2013, background): “There are two different, but inter-related, ER-dependent mechanisms, which are classified as either “genomic” and “nongenomic” [60], based on whether the end result of ER signaling is transcription regulation.”
• American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. (2010, background): “Estrogen signaling occurs via the standard classical steroid receptor mechanism.(11) Estrogen freely diffuses through the cellular membrane and binds monomeric ER protein, which seems to be almost exclusively nuclear even in the absence of ligand.”
• Estrogen signaling multiple pathways to impact gene transcription. (2006, background): “Both must be occupied for the E2 maximal activation [15].”
• Estrogen Rapidly Enhances Incisional Pain of Ovariectomized Rats Primarily through the G Protein-Coupled Estrogen Receptor (2014, background): “Several studies have shown that E2 can induce a rapid increase (within minutes and even seconds) of intracellular cAMP and Ca concentration through GPER [1,15–17].”