Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides.

By D. Topping, P. Clifton. Physiological Reviews, 2001

2,954 citations recorded by the source corpus.

Subfields: Genetics, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/237d7a8b05c5025bffdf0badc4f56ee334044454

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. H. Flint
2. S. Duncan
3. Antonio Gasbarrini
4. P. Gibson
5. A. Wolfe
6. P. Louis
7. Peter Bossier
8. Takuya Suzuki

In Nutrition and Dietetics

1. H. Flint
2. P. Louis
3. S. Duncan
4. K. Scott
5. G. Holtrop
6. K. Śliżewska
7. G. Lobley
8. A. Belenguer

Citations in the corpus

• The Acetate Switch (2005, background): “These SCFA, rapidly absorbed by the colonic mucosa, represent the primary energy source for colonocytes, hepatic cells, fat cells, and muscle cells (283, 284, 300, 313, 447).”
• Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut (2006, background): “For example, both resistant starch and FOS can be butyrogenic in vivo (23, 42, 43), although the main utilizers of such substrates so far identified have been lactic acid bacteria (31, 43).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “polysaccharides mainly found in plants and mammalian milk and dairy products (Topping and Clifton, 2001).”
• The structural characteristics of starches and their functional properties (2018, background): “…gums, dextrins (Philippe, 1995), in the elaboration of starch nanocrystals (Angellier, Molina-Boisseau, Dole, & Dufressne, 2006), resistant starch (Topping & Clifton, 2011), as well as in the encapsulation of various food components, such as probiotics that increase the number of beneficial…”
• Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, positive): “…acetate, propionate, and butyrate, are common end-products of carbohydrate-fermenting microbes in the distal gut (Wong et al., 2006), and several factors, including dietary substrates, can affect the relative ratios and concentrations (Macfarlane and Macfarlane, 2003; Topping and Clifton, 2001).”
• Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (2019, background): “0 Japanese, Chinese and Australian (43)”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “It is suggested that intestinal microbes generate short chain fatty acids from dietary carbohydrates that otherwise cannot be used as energy (Topping and Clifton, 2001; Gill et al., 2006; Turnbaugh et al., 2006).”
• Resistant starch: promise for improving human health. (2013, background): “Gut Bacterial Metabolism of Digestion-Resistant Starch Bacteria in the lower intestines of humans may be exposed to as much as 20 g of resistant starch per day (82).”
• Effect of extrusion conditions on resistant starch formation from pastry wheat flour (2006, background): “…to produce short-chain fatty acids, such as butyrate, has been associated with various health benefits, including lowering colorectal cancer risk (Escarpa, Gonzalez, Manas, GarciaDiz, & Saura-Calixto, 1996; Langkilde, Ekwall, Bjork, Asp, & Andersson, 1998; Niba, 2002; Topping & Clifton, 2001).”
• Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “One of the most important roles of the gut microbiota is to catabolize dietary fibers that are not completely hydrolyzed by the host enzymes during digestion [7].”
• Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “Dysregulation of any of the aforementioned components have been implicated, not only in the pathogenesis of IBD, but in many other GI disorders, including infectious enterocolitis, IBS, small intestinal bowel overgrowth, celiac sprue, hepatic fibrosis, atopic manifestations and food intolerance [34-”
• Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 (2012, background): “Intraluminal concentrations beyond 100 mmol/L, comprising ~60% acetate (C2), 25% propionate (C3), and 15% butyrate (C4), have been reported (8).”
• Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings (2010, background): “produce short-chain fatty acids which may lead to the reduced incidence of gastrointestinal disease [23], cancers [24] and cardiovascular diseases [25]; and improvement of lipid profiles [26].”